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Tag: Proton Pump Inhibitors

Proton pump inhibitors don't appear to increase the risk of dementia

PPIs Not Found to Raise Risk of Alzheimer’s Disease

New research debunks other studies suggesting that PPIs cause mental decline
For patients with dementia

Proton Pump Inhibitor Use Ups Pneumonia Risk in Dementia

Independent risk factors for pneumonia include age, male gender, underlying cerebrovascular disease
Use of gastric acid suppressants may increase the risk of recurrent Clostridium difficile infection

Gastric Acid Suppressants May Up Risk of Recurrent C. difficile

Meta-analysis shows increased risk of recurrent CDI, even after adjustment for age and confounders
For patients with Barrett's esophagus

No Chemopreventive Effect Seen for H2RAs in Barrett’s Esophagus

PPI use, but not H2 receptor antagonists, linked to reduced risk of progression in Barrett's esophagus
Women who take acid-suppressing medications during pregnancy may have a child at increased risk of developing asthma

Acid Suppression in Pregnancy Linked to Childhood Asthma

Review suggests, but doesn't prove, offspring one-third more likely to see a doctor for asthma
Proton pump inhibitor and H2 receptor antagonist users may be at higher risk of infection with Clostridium difficile and Campylobacter bacteria

Acid Suppression Rx Linked to Risk of C. difficile, Campylobacter

Study suggests long-term use might open door to C. difficile and Campylobacter bacteria
For patients beginning warfarin therapy

PPI Cuts Risk of Warfarin-Related Upper GI Bleeding

Greatest reduction in risk seen for patients also taking antiplatelet drugs or NSAIDs
Thirty-seven percent of premature infants receive gastroesophageal reflux medications

Preemies Often Receive Gastroesophageal Reflux Meds

Seventy-seven percent of those on medications started after NICU discharge; prolonged use common
Long-term proton pump inhibitor use is associated with increased risk of fundic gland polyps

Review Links PPI Use With Risk of Fundic Gland Polyps

Proton pump inhibitor therapy may also be associated with increased risk of gastric cancer
Acid suppression therapy is associated with increased incidence of kidney stones and chronic kidney disease

ASN: Acid Suppression Therapy Linked to Kidney Stones, CKD

Two studies show increased risk of kidney stones with PPI, H2 blocker use; CKD with PPI use