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Women taking aromatase inhibitors may show signs of early endothelial dysfunction that could lead to cardiovascular disease

SABCS: Aromatase Inhibitors Tied to Reduced Endothelial Function

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Women on aromatase inhibitors exhibit less elasticity in their blood vessels
Osimertinib is more effective than platinum-pemetrexed therapy in patients with T790M-positive advanced non-small-cell lung cancer whose disease has progressed during first-line epidermal growth factor receptor tyrosine kinase inhibitor treatment

Osimertinib Bests Platinum-Pemetrexed in T790M+ NSCLC

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Significantly longer duration of progression-free survival with osimertinib vs platinum-pemetrexed
An experimental drug for infants with spinal muscular atrophy type 1 appears to be effective

Nusinersen Shows Promise in Spinal Muscular Atrophy

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Study results are promising but do not represent a cure
Cardiac arrest patients who receive epinephrine within five minutes are more likely to survive than those who don't receive the drug within that time frame

Timely Epinephrine Increases Cardiac Arrest Survival

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Dose within five minutes of cardiac arrest increases chances by 20 percent
Older breast cancer survivors taking letrozole for more than the recommended five years may not live longer; however

SABCS: No Survival Benefit Seen for Letrozole Beyond Five Years

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Study found women who continued with letrozole did experience other benefits, however
For veterans with dementia

Potentially Unsafe Med Scripts Up for Dual Users With Dementia

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Rates of PUM are higher among veterans with dementia using VA-Medicare Part D system
A proposed biosimilar is comparable to trastuzumab for women with ERBB2-positive metastatic breast cancer

Biosimilar Promising for ERBB2+ Breast Cancer Treatment

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Equivalent response rate for women with ERBB2-positive metastatic breast cancer receiving taxanes
High-dose crizanlizumab treatment is associated with a significantly lower rate of sickle cell-related pain crises than placebo

ASH: Lower Rate of Sickle Cell Pain Crises With Crizanlizumab

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Lower rate of crises per year; longer median time to first, second crises with high-dose therapy
For patients with human epidermal growth factor receptor 2-overexpressing early breast cancer

Meds Don’t Cut Trastuzumab-Tied Left Ventricular Remodeling

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However, perindopril, bisoprolol do protect against declines in LVEF in HER2-positive early breast cancer
A novel selective JAK-1 inhibitor

ABT-494 Effective for Patients With Rheumatoid Arthritis

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Studies show effectiveness for those with inadequate response to MTX or at least one anti-TNF agent