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Esketamine seems to be efficacious and safe for patients with treatment-resistant depression

Esketamine Safe, Effective for Treatment-Resistant Depression

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Change in Montgomery-Åsberg Depression Rating Scale score superior for esketamine versus placebo
Although patients with pre-existing autoimmune disease who receive checkpoint inhibitors (CPIs) are at risk for exacerbation of their disease

Immune-Related Adverse Events Up With Checkpoint Inhibitors

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Most patients with cancer, autoimmune disease have improvement in events without discontinuing therapy
For patients with chronic obstructive pulmonary disease

CVD Risk Up With β2-Agonist, Antimuscarinic Antagonist Start

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New use of long-acting β2-agonists, antimuscarinic antagonists tied to higher CVD risk in first 30 days
For patients with acute severe ulcerative colitis

Predictors of Infliximab Response in Ulcerative Colitis Identified

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Baseline Mayo Endoscopic Score, CRP/albumin ratio predict treatment response and risk for colectomy
Few modern

Few Immuno-Oncology Agents Reach ASCO Efficacy Thresholds

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Durable survival, response rates rarely recognized as significant by current oncology value frameworks
Pharmaceutical aids are not effective for increasing long-term smoking cessation

Pharmaceutical Aids Not Found to Be Helpful for Smoking Cessation

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No evidence that varenicline, bupropion, or nicotine replacement increase probability of abstinence
From 2002 to 2015 there was a substantial increase in gabapentinoid use

Increase Seen in Gabapentinoid Use From 2002 to 2015

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More than three-fold increase in percentage of adults using gabapentin and/or pregabalin
Across cancers

Out-of-Pocket Costs Correlate With Receipt of Cancer Care

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Across cancers, higher costs tied to higher rates of oral prescription abandonment, delayed initiation
More than one-third of patients with newly diagnosed epilepsy do not respond to treatment with antiepileptic drugs

More Than a Third of Patients Do Not Respond to Antiepileptics

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Overall, 89.9 percent of patients who achieve seizure control do so with first, second AED regimen
Rituximab treatment seems effective for systemic lupus erythematosus-associated immune cytopenias

Rituximab Effective for Lupus-Associated Cytopenia

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Overall initial response rate of 86 percent in 71 patients, with complete response for 60.5 percent