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Metformin has therapeutic potential as a post-ischemic conditioning agent

Metformin Therapeutic As Post-Ischemic Conditioning Agent

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Metformin maintains cell viability and membrane stability of cardiomyoblast cells from ischemic injury
New measures to increase the number of generic prescription drugs available to Americans have been taken by the U.S. Food and Drug Administration.

FDA Seeks to Increase Number of Generic Drugs on Market

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Agency will now give priority reviews to new generic drugs until there are at least three available
For patients with acute myeloid leukemia and a FLT3 mutation

Longer Survival for Midostaurin + Chemotherapy in AML With FLT3

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Prolonged overall, event-free survival for patients with acute myeloid leukemia, FLT3 mutation
Patients with cancer frequently have herb-drug interactions and drug-drug interactions

Drug, Herb Interactions Frequent for Cancer Patients

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Concomitant use of two or more drugs independently linked to high risk of clinically significant DDI
Conjugated linoleic acid supplementation is associated with an increase in serum C-reactive protein concentration

Review Links Conjugated Linoleic Acid Supplementation to CRP

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Increase in serum C-reactive protein concentration following supplementation with CLA
For patients with epilepsy

Valproic Acid Concentration Drops With Ketogenic Diet

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Changes in serum concentrations of other anti-epileptic drugs not found to be significant
Isotretinoin may impair wound healing after tattooing

Isotretinoin May Impair Wound Healing After Tattoo

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Case report describes 19-year-old woman who had unsatisfactory aesthetic result from tattooing
For Caucasian patients with chronic hepatitis B

HCC Drops Beyond Five Years of Entecavir/Tenofovir Tx for Hep B

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Older age, lower platelets at baseline and year five, liver stiffness ≥12 kPa linked to HCC development
For development of oncology drugs in Japan

Strategies Compared for Cancer Medication Submission Lags

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Shorter submission lag for global trial, early-initiation bridging strategy vs late-initiation strategy
For patients with acute heart failure

Early Loop Diuretic Tx Tied to Lower Mortality in Heart Failure

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Early-treatment group had significantly lower in-hospital mortality even after adjustment