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Insurers are increasingly denying prescriptions of direct-acting antiviral drugs for hepatitis C virus treatment

One-Third of Hep C Rx Receive Absolute Denial From Insurers

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Both private and public insurers continue to deny coverage for drugs at high rates
Sulfonylureas as second-line drugs for type 2 diabetes are associated with an increased risk of cardiovascular and hypoglycemic events compared with remaining on metformin monotherapy or adding to metformin therapy

Sulfonylureas As 2nd-Line T2DM Therapy Tied to Higher Event Risk

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Associated with increased risk of myocardial infarction, all-cause mortality, severe hypoglycemia
There has been a substantial increase in the percentage of patients with high cholesterol over age 60 years taking lipid-lowering medications from 2005 to 2016

CDC: More People With High Cholesterol Taking Medications

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Findings only among men and women over 60 years, not younger patients with high cholesterol
Walmart's Generic Drug Discount Program

Walmart Generic Drug Discounts Often Offer More Patient Savings

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Walmart drug program offers savings over Medicare program for generic cardiovascular medications
Empagliflozin does not increase the risk of bone fracture in patients with type 2 diabetes

Empagliflozin Doesn’t Up Risk of Bone Fractures

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Per pooled data from placebo-controlled trials and data from a head-to-head study with glimepiride
Availability of generic antivirals for treating chronic hepatitis B virus is increasing

Availability of Generic Antivirals for Hepatitis B Increasing

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Drop in median price of WHO-prequalified generic tenofovir from $208 to $32 from 2004 to 2016
For patients with sickle cell-related pain

L-Glutamine Reduces Number of Pain Crises in Sickle Cell Disease

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Significantly fewer pain crises, hospitalizations compared with those receiving placebo
Basal insulin analogues for type 2 diabetes mellitus do not substantially differ in their glucose-lowering effect

Basal Insulin Analogues Similar for Glucose Lowering

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Slight differences in risk for nocturnal hypoglycemia or weight gain exist
The percentage of U.S. men receiving testosterone prescriptions decreased from 2013 through 2016

Testosterone Prescribing Down Since 2013

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Decline coincided with reports linking testosterone to adverse cardiovascular events
Many patients with type 2 diabetes who have a hemoglobin A1c level expected to trigger treatment intensification often have treatment inappropriately delayed

Evidence of Clinical Inertia in Management of T2DM

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No treatment intensification for many patients with HbA1c threshold expected to trigger intensification