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For left ventricular assist device recipients

PDE5i Use Linked to Post-LVAD Right Heart Failure Events

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Incidence of severe early right heart failure higher among patients on preimplant PDE5i than controls
Valproic acid and topiramate are confirmed teratogens

Study Confirms Teratogenicity of Valproic Acid, Topiramate

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Eight specific types of major congenital malformations associated with prenatal exposure to valproic acid
Dulaglutide is associated with a reduction in cardiovascular events and renal outcomes among patients with type 2 diabetes

ADA: Dulaglutide Tied to Decline in Cardiovascular Events in T2DM

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Second study shows reduction in renal outcomes with dulaglutide in type 2 diabetes
The U.S. Preventive Services Task Force recommends preexposure prophylaxis and HIV screening for prevention of HIV infection. These recommendations form the basis of two final recommendation statements published online June 11 in the Journal of the American Medical Association.

USPSTF Issues Recommendations on HIV Screening, Prevention

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Recommendations support PrEP for those at high HIV risk, screening for teens, adults, in pregnancy
There is variability in data relating to the safety of lithium during breastfeeding

Data Insufficient for Safety of Lithium During Breastfeeding

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Lithium transfer to infants is variable; three cases of adverse effects reported, but confounding occurred
Nonmedical use of alprazolam is a significant issue in the United Kingdom

Misuse of Alprazolam Common in the United Kingdom

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Survey shows nonmedical use of the antianxiety drug is most common among younger adults
Only one-third of Philadelphia pharmacies carry naloxone nasal spray and many pharmacies require a physician's prescription

Naloxone Available in One in Three Philadelphia Pharmacies

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In chain stores, naloxone was more likely to be in stock and to be available without a prescription
For men with metastatic

ASCO: Enzalutamide Beneficial in Metastatic Prostate Cancer

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Progression-free, overall survival longer for men with metastatic, hormone-sensitive prostate cancer
Maintenance therapy with olaparib is associated with improved progression-free survival in metastatic pancreatic cancer patients with a germline BRCA1 and/or BRCA2 mutation

ASCO: Olaparib Beats Placebo for BRCA-Related Pancreatic Cancer

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Progression-free survival significantly improved with olaparib versus placebo for metastatic disease
β-blockers can attenuate the impact of anger or stress on atrial fibrillation

β-Blockers May Moderate Impact of Stress on Atrial Fibrillation

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Likelihood of atrial fibrillation episode up during anger or stress; β-blockers can attenuate effect