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Elderly patients with inflammatory bowel disease are at higher risk for adverse events related to the use of thiopurines

Elderly Who Start Thiopurine Tx for IBD Have Higher Risk for AEs

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Advanced age, female gender are independent risk factors for adverse events
Uptitration of drugs for chronic systolic heart failure stops farther away from the recommended dosage for drugs with higher versus lower recommended dosages

Uptitration of Drugs Varies With Target Dosage in Chronic HF

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When target is higher versus lower dosage, uptitration stops further from recommended dosage
For patients with progressive fibrosing interstitial lung diseases

Nintedanib Slows Fibrosing Interstitial Lung Disease

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Nintedanib linked to lower rate of decline in forced vital capacity versus placebo in phase 3 trial
Heart disease is associated with an increased risk for hospital admission for allopurinol-associated severe cutaneous adverse reactions

Heart Disease May Up Risk for Allopurinol-Linked Cutaneous AEs

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Risk for hospital admission increased for allopurinol-associated severe cutaneous adverse reactions
Ticagrelor alone results in less bleeding than ticagrelor plus aspirin among high-risk patients who have undergone percutaneous coronary intervention and received dual antiplatelet therapy for three months

Less Bleeding With Ticagrelor Alone in High-Risk Patients

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Less bleeding with ticagrelor alone versus ticagrelor plus aspirin for patients after PCI
Short-term use of a dipeptidyl peptidase 4 inhibitor for the treatment of diabetes does not increase the risk of inflammatory bowel disease

DPP4 Inhibitors Do Not Up Risk of Inflammatory Bowel Disease

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Findings based on comparison to sulfonylureas, thiazolidinediones
Cardiovascular adverse drug reactions occur in association with ibrutinib

Severe Adverse Cardiovascular Events Associated With Ibrutinib

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Risk up for severe, sometimes fatal, events, including supraventricular arrhythmias, CNS events
In contrast to findings in black adolescents and adults

Step-Up Strategy May Differ in Black Children With Asthma

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Poorly controlled asthma in black children may respond to increased dose of inhaled glucocorticoid
In moderate-to-severe ulcerative colitis

Vedolizumab Beats Adalimumab for Ulcerative Colitis Remissions

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But not for corticosteroid-free clinical remission; also, ustekinumab superior to placebo
The recall of the commonly prescribed blood pressure drug losartan has been expanded once again to include an additional five lots.

More Blood Pressure Drugs Recalled

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Some lots of losartan contaminated with the cancer-causing chemical N-methylnitrosobutyric acid