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An expert panel for the U.S. Food and Drug Administration has endorsed a drug for major depressive disorder that is a close relative to ketamine.

FDA Panel Backs Ketamine-Like Drug for Depression

Esketamine is a nasal spray that targets different pathways in the brain than other antidepressants do
For adults with chronic hepatitis C virus infection

Direct-Acting Antivirals Cut Mortality in Chronic Hepatitis C

Mortality, hepatocellular carcinoma risk reduced after adjustment for potential confounders
The reversal agent

ASA: Reversal Agent Cuts Severe Bleeding With Factor Xa Inhibitors

Bolus plus two-hour infusion of andexanet alfa cuts antifactor Xa activity by 92 percent
In a drug industry first

Johnson & Johnson to Provide Drug Prices in TV Ads

Drug list prices, typical out-of-pocket costs will appear on screen at end of commercials
Lumacaftor/ivacaftor treatment is generally safe and well tolerated for children aged 2 to 5 years with cystic fibrosis homozygous for the F508del-CFTR mutation

Drug Combo Tolerated in Younger Children With Cystic Fibrosis

Lumacaftor/ivacaftor safe in children ages 2 to 5 with cystic fibrosis homozygous for F508del-CFTR
Treatment of psoriasis with biologic therapy is associated with a reduction in noncalcified coronary plaque and improved plaque morphology

Psoriasis Tx Linked to Drop in Noncalcified Coronary Plaque

Noncalcified plaque burden and necrotic core reduced in association with biologic therapy
The clinical benefits of tofacitinib in combination with methotrexate are sustained over two years among patients with rheumatoid arthritis

Tofacitinib Benefits Sustained for Two Years in Patients With RA

Safety, tolerability through 24 months was consistent with 12-month tofacitinib analysis
A pharmacist-led

Pharmacist-Led Phone Follow-Up May Cut Readmission Rates

Intervention for polypharmacy patients linked to improved readmission rates, time to readmission
Discontinuing tumor necrosis factor inhibitors before gestational week 20 in women with well-controlled rheumatoid arthritis or juvenile idiopathic arthritis is not associated with disease worsening in late pregnancy

Discontinuing TNFi Before Gestational Week 20 Is Feasible

No clinically meaningful disease worsening among women with well-controlled RA, juvenile arthritis
A shortage of the anti-anxiety drug buspirone in the United States has patients and doctors concerned.

Shortage of Anxiety Drug Creates Alarm Among Patients, Doctors

Buspirone price has fallen so low that many manufacturers claim they cannot make a profit on it