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Tag: Multiple Myeloma

La vacuna de Pfizer contra la COVID parece promisoria

ASH: Adding Subcutaneous Daratumumab Slows Advanced Multiple Myeloma

Subcutaneous daratumumab plus pomalidomide and dexamethasone reduces risk of progression, death in relapsed/refractory MM

Triplet Therapy Slows Refractory Multiple Myeloma

Progression-free survival longer with once-weekly selinexor-containing regimen versus standard bortezomib and dexamethasone

For patients with multiple myeloma and COVID-19

COVID-19 Case Fatality Rate 29 Percent in Multiple Myeloma Patients

Increased odds of adverse outcomes seen for Hispanic/Latinos, African-American Blacks versus white patients
Vitamin D deficiency is associated with reduced overall survival for patients with multiple myeloma

Low Vitamin D May Reduce Survival for Some With Multiple Myeloma

Differential effect seen by race, with significantly lower OS for white but not African-American patients
For patients with multiple myeloma treated with autologous stem cell transplantation

Outcomes Steadily Improve for Multiple Myeloma Treated With ASCT

Patients treated in 2014 or later had superior OS, reduced excess risk for multiple myeloma death
For patients with multiple myeloma receiving focal radiation therapy for symptomatic plasmacytoma

Reirradiation Rarely Required in Focal RT for Multiple Myeloma

For biologically effective dose ≤28 Gy10, small but significant increase seen in reirradiation rates
A frailty scale that includes Eastern Cooperative Oncology Group performance status may predict outcomes for transplant-ineligible patients with newly diagnosed multiple myeloma

Frailty Score May Predict Outcomes in Multiple Myeloma

Frailty score based on age, Charlson Comorbidity Index, ECOS PS predicts outcomes in FIRST trial
Lenalidomide significantly delays progression to symptomatic multiple myeloma in patients with smoldering multiple myeloma

Lenalidomide Delays Progression in Smoldering Multiple Myeloma

Progression-free survival significantly longer with lenalidomide compared with observation
Different racial/ethnic groups with multiple myeloma have significant variations in novel therapy and autologous stem cell transplant use

Use of Novel Therapy, Stem Cell Transplant in MM Varies by Race

African-Americans, Hispanics have longer time from MM diagnosis to novel therapy initiation than whites
Most dimensions of quality of life (QoL) are impaired in patients with relapsed/refractory multiple myeloma

Effects on Quality of Life Mixed for Tx of Multiple Myeloma

Reduced pain but worsening of neuropathy seen for IxaThalDex induction tx in relapsed/refractory MM