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Tag: Hormone Replacement Therapy

Hormone therapy does not significantly impact muscle mass in postmenopausal women

Hormone Tx Not Tied to Change in Muscle Mass in Older Women

No significant beneficial or detrimental association seen in postmenopausal women
Women with premature ovarian insufficiency receiving hormone therapy have poor sleep quality

Premature Ovarian Insufficiency Tied to Poor Sleep Quality

Patients take longer to fall asleep, use more sleep aids, have more fatigue
Long-term use of systemic hormone therapy may be associated with an increased risk for Alzheimer disease

Long-Term Systemic Hormone Therapy May Up Alzheimer Risk

Risk increases associated with hormone therapy exposure over 10 years in women <60 years at initiation
People receiving hormone therapy during gender transition have an increased risk for cardiovascular events

Cardiovascular Risk Increased During Gender Transition

Transwomen had higher incidence of strokes, VTEs than reference men and women
For postmenopausal women

Prevalence of Knee OA Lower With Menopausal Hormone Therapy

Odds ratio for knee osteoarthritis was 0.7 in MHT group versus non-MHT group in multivariable model
The Women's Health Initiative recommendations for menopausal hormone therapy use issued in 2002 have been widely adopted

Menopausal Hormone Tx Use Down Post-WHI Recommendations

But large declines seen in subgroups for whom MHT is recommended, including younger women
Oral hormone replacement therapy is associated with an increased risk for venous thromboembolism

Transdermal HRT Not Linked to Increased Risk for VTE

But oral estrogen-only and combined hormone replacement tx tied to venous thromboembolism risk
Women who receive menopausal hormone therapy have reduced age-adjusted visceral adipose tissue

Menopausal Hormone Therapy Linked to Reduced Abdominal Fat

No residual effect for past users, including early discontinuers of menopause hormone treatment
Taking menopausal hormone therapy may have long-term effects on the brain

Hormone Therapy May Impact Brain Structure, Cognition

But 3 years after menopausal HT, change in brain volumes not significantly different from placebo
Menopausal hormone therapy use is associated with less pronounced kyphosis compared with never-use

Menopausal Hormone Therapy Tied to Less Pronounced Kyphosis

Continuous and remote past HT users had less kyphosis in minimally-, fully-adjusted models