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Tag: Heartburn / GERD / Indigestion

Conservative measures to control reflux have limited effect on signs of gastroesophageal reflux in preterm infants

Pharmacologic Tx Should Be Used Sparingly for Reflux in Preemies

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Poor evidence of efficacy and evidence of harm with pharmacologic agents for gastroesophageal reflux
For patients with minor psychiatric disorders

DDW: Psych Disorders Make GERD Hard to Dx by Symptoms Alone

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Symptoms are unreliable for establishing presence of reflux in patients with minor psychiatric disorders
Diaphragmatic breathing can reduce belching and proton pump inhibitor-refractory gastroesophageal reflux

Diaphragmatic Breathing Tied to Less Belching in GERD

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The therapy is associated with reduced symptoms in patients with PPI-refractory gastroesophageal reflux
Gastroesophageal reflux disease is associated with a higher risk of cancer in the upper aerodigestive tract among the elderly population in the United States

GERD Linked to Upper Aerodigestive Tract Cancers

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In elderly, tied to higher odds of malignancy in larynx, hypopharynx, oropharynx, nasopharynx
Children with CYP2C19*17 alleles without corresponding loss-of-function alleles have longer times with pH <4 in response to proton pump inhibitor medication

CYPC19*17 Allele May Influence Response to PPI Treatment

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Kids with CYPC19&#42;17 alleles without corresponding loss-of-function alleles have longer times with pH &#60;4
Laparoscopic antireflux surgery is associated with a relatively high rate of recurrent gastroesophageal reflux disease

Antireflux Surgery Has High Rate of Recurrent Disease

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Nearly 18 percent have recurrence requiring long-term medication, secondary surgery
For infants with gastroesophageal reflux disease

Variation in Management for Infants With GERD

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Variation in overall utilization of anti-reflux surgery, and in surgical and diagnostic approach
For patients with gastroesophageal reflux disease

HRQoL Down for GERD With Laryngopharyngeal Reflux

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Significantly lower mean EuroQoL-5D scores for gastroesophageal reflux disease with LPR symptoms
For patients with gastroesophageal reflux disease

Sleep Disturbance Linked to Esophageal Hypersensitivity

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Patients with sleep disturbance have enhanced heartburn perception to capsaicin infusion
Thirty-seven percent of premature infants receive gastroesophageal reflux medications

Preemies Often Receive Gastroesophageal Reflux Meds

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Seventy-seven percent of those on medications started after NICU discharge; prolonged use common