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For patients with heart failure and reduced ejection fraction

Sacubitril-Valsartan Does Not Impact Aortic Stiffness in HFrEF

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But it is linked to improvements in cardiac structure, function including decreases in LVESVI, LVEDVI
Elevated left ventricular mass is associated with an increased long-term risk for cardiovascular events

LV Hypertrophy Predicts Long-Term Risk for CV Events

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Left ventricular hypertrophy stronger predictor than CAC for CHD death, other CV death, heart failure
Persons living with HIV who are hospitalized with heart failure are at an increased risk for subsequent sudden cardiac death

Poor HIV Control Ups Risk for Sudden Cardiac Death in Heart Failure

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Lower CD4 count, nonsuppressed viral load linked to higher risk for sudden cardiac death in HIV with heart failure
For patients with heart failure

Type 2 Diabetes Associated With Poorer Outcomes in Heart Failure

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Findings include structural abnormalities in the heart, poorer quality of life with T2DM and HF
An infusion of serelaxin does not result in a lower incidence of death from cardiovascular causes or worsening of heart failure among patients hospitalized for acute heart failure

Serelaxin Does Not Lower CV Death in Acute Heart Failure

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No drop in incidence of death at 180 days or worsening of heart failure seen for hospitalized patients
Genetic liability to insomnia is associated with increased odds of major cardiovascular diseases

Genetic Liability to Insomnia Linked to Increased Odds of CVDs

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Mendelian randomization analyses revealed greater odds of CAD, heart failure, ischemic stroke
The excess risk for heart failure associated with diabetes is significantly greater in women than men

Excess Risk for Diabetes-Linked Heart Failure Greater in Women

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Women with type 1, type 2 diabetes have greater excess risk for heart failure versus men
Medicare Advantage patients have higher risk-adjusted hospital readmission rates than traditional Medicare patients for acute myocardial infarction

Medicare Advantage Patients Have Higher Readmission Rates

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Higher adjusted readmission rates seen for AMI, CHF, pneumonia with Medicare Advantage
Cardiac resynchronization therapy with defibrillator implantation is associated with better outcomes than an implantable cardioverter-defibrillator for patients with nonspecific intraventricular conduction delay but not for those with right bundle branch block

Some Heart Failure Patients May Benefit From CRT Defibrillator

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Findings seen in patients with non-left bundle branch block eligible for cardiac resynchronization therapy
For left ventricular assist device recipients

PDE5i Use Linked to Post-LVAD Right Heart Failure Events

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Incidence of severe early right heart failure higher among patients on preimplant PDE5i than controls