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Untreated gestational diabetes is associated with development of subsequent glucose metabolism disorders in mothers

Gestational Diabetes Tied to Subsequent Glucose Disorders

Long-term effects seen in mothers, but offspring not significantly overweight, obese
First-trimester glycated hemoglobin may aid in early identification of women at risk for gestational diabetes mellitus

Increased First-Trimester HbA1c Predicts Gestational Diabetes

First-trimester HbA1c significantly improves GDM prediction compared with conventional risk factors
Higher free triiodothyronine levels

Thyroid Dysfunction Linked to Gestational Diabetes

fT3 and fT3-to-fT4 ratio correlated positively with gestational diabetes at the first and second trimester
Uniform application of gestational diabetes mellitus diagnostic thresholds may not be appropriate in populations across the world

Single Threshold May Not Be Feasible for Gestational Diabetes

Diagnostic thresholds should be adapted using local populations, authors say
Gestational diabetes mellitus may be an early indicator of subsequent subclinical renal dysfunction

Gestational Diabetes May Indicate Future Subclinical Renal Issues

Women who had gestational diabetes more likely to show increased eGFR levels many years postpartum
For women with gestational diabetes

Glyburide Not Noninferior to Insulin for Gestational Diabetes

Frequency of primary outcome was 27.6 and 23.4 percent in glyburide and insulin groups, respectively
Higher pre-pregnancy fitness lowers the risk of gestational diabetes mellitus

Pre-Pregnancy Fitness Lowers Gestational Diabetes Risk

However, self-reported physical activity and television time not tied to diabetes risk
For women with previous gestational diabetes mellitus

Lactation Lowers Risk of T2DM After Gestational Diabetes

Compared to no lactation, long-term lactation of more than 1 to 3 months not linked to T2DM risk
Laparoscopic sleeve gastrectomy is associated with a lower rate of gestational diabetes mellitus and excessive fetal growth

Sleeve Gastrectomy Tied to Drop in GDM, Excessive Fetal Growth

Laparoscopic sleeve gastrectomy also tied to SGA and low birth weight neonates, lower c-section rates
Teenage offspring of mothers with gestational diabetes mellitus have increased adiposity and an adverse cardiometabolic profile

Maternal GDM Tied to Child’s Cardiometabolic Profile

Female offspring of mothers with gestational diabetes have earlier onset of puberty than controls