Tag: Genetics
Prevalence of Key Cancer Susceptibility Genes Higher Than Expected
Study reveals 5.05 percent of individuals carry pathogenic/likely pathogenic variants in in large, unselected U.S. population
Two HLA Class I Alleles Independently Linked to Allopurinol-Induced SCARs
HLA-B*58:01 and HLA-A*34:02 linked to increased risk, while no HLA class II alleles were identified
Gene Expression Profile Test IDs Patients Who Can Skip SLNB in Melanoma
Of patients identified as low risk by combined clinicopathological factors and GEP test, only 7.1 percent were SLN-positive
Niraparib Plus AAP Improves Survival in mCSPC With HRR Gene Alterations
Significant improvement in radiographic progression-free survival seen first in BRCA subgroup
Estimates of Breast CA Risk for Pathogenic Variants Vary by Family Hx
Estimates for established pathogenic variants vary by family history and potentially modifiable risk factors
Polygenic Risk Score 313 Can Predict Risk for Breast Cancer After In Situ Disease
Significant association seen for increasing continuous PRS313 and risk for contralateral disease after DCIS
Early Exposure to Dogs May Reduce Risk for Childhood Asthma
No link seen between early exposure to cat allergens and asthma risk
Physical Frailty May Contribute to Risk for Dementia Development
Potential causal relationship seen between physical frailty and dementia in forward MR analysis, but null association seen in reverse MR
Aspirin Linked to Lower CRC Recurrence for Molecularly Defined Subgroup
Significantly lower incidence of colorectal cancer recurrence seen for patients with somatic alterations in PI3K pathway genes
Smoking Tied to Increased Risk for Type 2 Diabetes
People with a genetic susceptibility to developing diabetes may be more vulnerable to the adverse effects of smoking
