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Tag: Cancer: Ovarian

Deleterious mutations in RAD51C and RAD51D genes are associated with increased risk of epithelial ovarian cancer

RAD51 Mutations Confer Moderate Risk of Ovarian Cancer

RAD51C and RAD51D deleterious mutations linked to increased risk of epithelial ovarian cancer
Multigene testing for hereditary breast and/or ovarian cancer identifies more mutations that are likely to change clinical management

Multigene Test IDs More at Risk for Hereditary Breast/Ovarian CA

Testing for mutations other than BRCA1/2 in HBOC may change clinical management for women, families
About thirty percent of women with epithelial ovarian cancer survive for more than 10 years

~30 Percent With Epithelial Ovarian CA Survive Long Term

Predictors for long-term survival include younger age, early stage, low grade, non-serous histology
Intraperitoneal chemotherapy significantly improves survival among women with advanced ovarian cancer; however

Intraperitoneal Chemotherapy Ups Ovarian Cancer Outcomes

However, only 41 percent of suitable candidates actually receive the therapy
The R-enantiomer of ketorolac is enriched in peritoneal fluids and inhibits peritoneal cell GTPase activity with administration after ovarian cancer surgery

Novel Pharmacological Activity for R-Ketorolac in Ovarian Cancer

R-enantiomer enriched in peritoneal fluids, inhibits peritoneal cell GTPase activity
Chemotherapy dose reduction is associated with worse survival in ovarian cancer

Worse Survival With Chemo Dose Reduction in Ovarian Cancer

Lower average relative dose intensity linked to worse overall and ovarian cancer-specific survival
Undergoing chemotherapy before surgery may help women battling advanced ovarian cancer

Benefits for Surgery Before Chemo in Advanced Ovarian CA

Appears to raise quality of life without shortening survival
Screening with a multimodal strategy

Multimodal Strategy Improves Ovarian Cancer Detection

Screening using risk of ovarian cancer algorithm linked to increased number of screen-detected iEOCs
Women diagnosed with ovarian cancer are now much more likely to survive the disease than they were several decades ago

Survival Improving for Women With Ovarian Cancer

Women diagnosed today 50 percent less likely to die than they were in the 1970s
Salpingectomy alone may be a risk management option for women at hereditary risk of ovarian cancer

Review Examines Salpingectomy Alone for Cutting Ovarian CA Risk

Recent evidence suggests fallopian tube epithelium is origin of most high-grade serous cancers