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Initiating donepezil to manage symptoms of Alzheimer disease or other dementias is associated with a higher risk for 30-day admission to the hospital with rhabdomyolysis compared with initiating rivastigmine or galantamine

Donepezil Ups Risk for Hospital Admission for Rhabdomyolysis

Donepezil linked to increased risk for admission with rhabdomyolysis versus rivastigmine, galantamine
Donepezil should not be prescribed to patients with mild cognitive impairment without first giving them a genetic test

Off-Label Donepezil Rx for MCI Could Be Risky for Some Patients

Medication has detrimental effect on patients with the K-variant of the butyrylcholinesterase gene