Home Cardiology Proton Pump Inhibitor Use Not Linked to Cardiac Arrhythmia

Proton Pump Inhibitor Use Not Linked to Cardiac Arrhythmia

In adjusted analyses, no increased risk of arrhythmia with PPI use for critically ill patients

MONDAY, Feb. 23, 2015 (HealthDay News) — In critically ill patients, proton pump inhibitor (PPI) use is not associated with cardiac arrhythmia, according to a study published online Feb. 6 in the Journal of Clinical Pharmacology.

Kenneth P. Chen, M.D., from the Beth Israel Deaconess Medical Center in Boston, and colleagues examined whether PPI exposure correlated with admission electrocardiogram readings of a cardiac arrhythmia in a study involving more than 8,000 critically ill patients.

Within the cohort there were 25.4 percent PPI users and 6 percent taking a histamine 2 antagonist. Of the patients, 14.0 percent had a cardiac arrhythmia. The researchers found that the risk of arrhythmia in association with PPI use was 1.15 (95 percent confidence interval, 1.00 to 1.32; P = 0.04) in unadjusted analyses and 0.91 (95 percent confidence interval, 0.77 to 1.06; P = 0.22) in adjusted analyses. PPI use was not associated with increased risk of cardiac arrhythmia among diuretic users (2,476 patients).

“In summary, in a large cohort of critically ill patients, PPI exposure is not associated with an increased risk of cardiac arrhythmia,” the authors write.

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