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The U.S. Food and Drug Administration has strengthened current warnings in the prescribing information about fluoroquinolone antibiotics causing significant decreases in blood glucose as well as mental health side effects.

FDA Requires Safety Label Changes for Fluoroquinolones

Changes will describe hypoglycemic coma and clarify and identify mental health side effects
The U.S. Preventive Services Task Force concludes that there is currently insufficient evidence to assess the benefits and harms of adding nontraditional risk factors to traditional cardiovascular disease risk assessment in asymptomatic adults. These findings form the basis for a final recommendation statement published online July 10 in the Journal of the American Medical Association.

USPSTF: Evidence Lacking for Nontraditional CVD Risk Factors

Insufficient evidence for adding to traditional CVD risk assessment in asymptomatic adults
The U.S. Preventive Services Task Force concludes that there is currently insufficient evidence to assess the benefits and harms of screening for peripheral artery disease with the ankle branchial index in asymptomatic adults. These findings form the basis of a final recommendation statement published in the July 10 issue of the Journal of the American Medical Association.

USPSTF: Evidence Lacking for ABI for PAD Screen in Asymptomatic

No direct evidence, limited indirect evidence for benefits of PAD screening in asymptomatic population
Multivitamin/mineral supplementation seems not to be associated with cardiovascular disease outcomes

Taking Multivitamins/Minerals Doesn’t Improve CVD Outcomes

MVM use not linked to decreased CVD mortality, CHD mortality, stroke mortality, or stroke incidence
Metformin use is associated with an increased risk of acidosis at estimated glomerular filtration rate <30mL/min/1.73 m²

Metformin Tied to Acidosis Risk at eGFR <30mL/min/1.73 m²

Not linked to incident acidosis overall, in those with eGFR levels of 30 to 44, 45 to 59 mL/min/1.73 m²
Almost 3 percent of teenagers aged 13 to 18 years have food

Unhealthy Food Behaviors May Signal Eating Disorder in Teen

Signs include restricting more and more food groups, significant weight change, excessive exercise
Early introduction of solids is associated with significantly longer sleep and less-frequent waking for infants

Early Introduction of Solids Linked to Better Infant Sleep

Longer sleep duration, less frequent waking at night, and reduction in reported serious sleep problems
Use of electronic health record tools in isolation improves medication reconciliation but does not improve systolic blood pressure among patients with hypertension

EHR Tools Improve Medication Reconciliation in Hypertension

However, systolic blood pressure did not differ in the EHR-plus-education group and usual care group
The attending surgeon is associated with variation in the receipt of genetic testing after breast cancer diagnosis

Attending Surgeon Influences Genetic Testing in Breast Cancer

About one-third of surgeon variation explained by patient volume, surgeon attitudes to genetic testing
The incidence of treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC) is 17 percent among patients with metastatic castration-resistant prostate cancer

Advanced Prostate Cancer Variant More Common Than Thought

Incidence of tx-emergent small-cell neuroendocrine prostate cancer 17 percent among those with mCRPC