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No Independent Link for Fatty Pancreas, T2DM

After adjustment for confounding variables, no significant correlation remains

TUESDAY, Aug. 2, 2016 (HealthDay News) — After adjustment for confounding variables, fatty pancreas is not associated with type 2 diabetes mellitus (T2DM), according to a study published online July 15 in Diabetes Care.

Hajime Yamazaki, M.D., from Teine Keijinkai Hospital in Sapporo, Japan, and colleagues examined the correlation between fatty pancreas and T2DM in a cohort of 813 participants without diabetes who underwent health checks by unenhanced computed tomography (CT) scanning in 2008 and 2009. Participants were followed for a median of 5.06 years. The mean pancreatic attenuation was calculated based on measurement of attenuation in three regions of the pancreas on unenhanced CT scans, with lower attenuation for more severe fatty pancreas.

The researchers found that during follow-up T2DM occurred in 7.6 percent of participants. In univariate analysis, higher pancreas attenuation at baseline correlated with decreased incidence of T2DM (crude hazard ratio, 0.97; 95 percent confidence interval, 0.96 to 0.99); lower pancreas attenuation correlated with increased incidence of T2DM. After adjustment for confounders, the association was no longer significant (multivariate hazard ratio, 1.00; 95 percent confidence interval, 0.98 to 1.02).

“Fatty pancreas was not independently associated with future T2DM,” the authors write.

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