Home Pathology July 2016 Briefing – Pathology

July 2016 Briefing – Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for July 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Conception During Low Mosquito Activity May Lower Zika Odds

FRIDAY, July 29, 2016 (HealthDay News) — Women in Zika-affected countries might reduce their risk of infection during pregnancy by timing conception with periods of low mosquito activity, according to a perspective piece published July 28 in PLOS Biology.

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Biological Changes Real for Non-Celiac Wheat Sensitivity

FRIDAY, July 29, 2016 (HealthDay News) — There are clear biological changes in patients presenting with non-celiac wheat sensitivity, according to research published online July 25 in Gut.

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Early Mortality for Most Infants With Trisomy 13, 18

FRIDAY, July 29, 2016 (HealthDay News) — Early mortality is the most common outcome among children born with trisomy 13 or 18, although one-year survival is high for those undergoing surgical procedures, according to a study published online July 26 in The Journal of the American Medical Association.

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Esophageal Cancer Risk Raised by Alcohol Intake, Obesity

FRIDAY, July 29, 2016 (HealthDay News) — New research suggests that in the United States, a third of esophageal cancer cases — about 5,600 per year — could be prevented if people maintained a healthy weight and didn’t drink.

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Mitochondria-Targeted Iron Chelator Offers Photoprotection

FRIDAY, July 29, 2016 (HealthDay News) — A mitochondria-targeted iron chelator can protect primary skin fibroblasts against the harmful effects of ultraviolet A (UVA), according to a study published in the August issue of the Journal of Investigative Dermatology.

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Clinicians Should Consider Valley Fever in Some Flu Patients

THURSDAY, July 28, 2016 (HealthDay News) — Clinicians should suspect coccidioidomycosis, also known as San Joaquin Valley fever, in patients with pneumonia or ongoing flu-like symptoms who live in or have visited the west or southwest United States, especially Arizona and central California, according to updated guidelines from the Infectious Diseases Society of America (IDSA) published online July 27 in Clinical Infectious Diseases.

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Two More Possible Cases of Non-Travel-Related Zika in Florida

THURSDAY, July 28, 2016 (HealthDay News) — Florida health officials are investigating two more unexplained cases of Zika infection, bringing to four the number of cases that don’t seem to be related to travel to countries where the virus is circulating.

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Miscarriage Linked to Maternal Zika Infection

THURSDAY, July 28, 2016 (HealthDay News) — Dutch researchers are reporting a case of miscarriage tied to maternal infection with the Zika virus. The report was published online July 27 in the New England Journal of Medicine.

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Marijuana May Cause More Damage to Heart Than Tobacco

THURSDAY, July 28, 2016 (HealthDay News) — In an experimental study published online July 27 in the Journal of the American Heart Association, lab rats experienced substantially impaired endothelial function after a minute’s exposure to secondhand smoke (SHS) from marijuana.

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Potential New Asthma Genes ID’d in Genome-Wide Study

THURSDAY, July 28, 2016 (HealthDay News) — Potential new asthma genes have been identified in a genome-wide association study (GWAS) combined with subsequent lung expression quantitative trait loci (eQTL) analysis, according to research published online July 20 in Allergy.

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‘Ice Bucket Challenge’ Led to Significant ALS Gene Discovery

WEDNESDAY, July 27, 2016 (HealthDay News) — The hugely popular “Ice Bucket Challenge” funded a study that has discovered an important new amyotrophic lateral sclerosis (ALS) gene. The study, which involved more than 80 researchers in 11 countries, was published online July 25 in Nature Genetics.

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Flu Vaccine Protective Against Hospitalization, Death in T2DM

WEDNESDAY, July 27, 2016 (HealthDay News) — The seasonal influenza vaccine may significantly reduce mortality for patients with type 2 diabetes, as well as hospitalizations for stroke and cardiovascular and pulmonary issues, according to a study published online July 25 in CMAJ, the journal of the Canadian Medical Association.

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Blunted, More Variable Insulin Action in Lipohypertrophy

WEDNESDAY, July 27, 2016 (HealthDay News) — Insulin lispro injection into lipohypertrophic tissue (LHT) results in considerable impairment and increased variability in insulin absorption and action, according to a study published in online July 13 in Diabetes Care.

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USPSTF: Evidence Lacking to Recommend Skin Cancer Screens

TUESDAY, July 26, 2016 (HealthDay News) — There is insufficient evidence to recommend regular full-body exams for skin cancer as a means of preventing deaths from these cancers, according to a new review and recommendation statement published in the July 26 issue of the Journal of the American Medical Association.

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American Red Cross Says Blood Donations Needed Urgently

TUESDAY, July 26, 2016 (HealthDay News) — The American Red Cross says it has an urgent need for blood donations, with less than a five-day supply of blood on hand to help those who need it.

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Medical Students Often Track Progress of Former Patients

TUESDAY, July 26, 2016 (HealthDay News) — Many U.S. medical students use electronic health records to track the progress of their former patients and confirm the accuracy of their diagnoses, according to research letter published online July 25 in JAMA Internal Medicine.

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Delaying Pregnancy Could Reduce Risk of Zika Infection

TUESDAY, July 26, 2016 (HealthDay News) — For the population of Colombia, pregnancy delays of sufficient duration can reduce the risk of prenatal Zika virus infections, according to research published online July 26 in the Annals of Internal Medicine.

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Sex-Specific Role for Glucokinase in Autonomic Nervous Activity

TUESDAY, July 26, 2016 (HealthDay News) — Glucokinase (Gck) in the ventromedial hypothalamic nucleus (VMN) is involved in glucose-dependent control of autonomic nervous activity in female mice only, according to an experimental study published online July 15 in Diabetes.

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Recent Increases in Rate of Hep C Detection in Young Women

TUESDAY, July 26, 2016 (HealthDay News) — From 2011 to 2014 there were increases in the rate of hepatitis C virus (HCV) detection among women of childbearing age, according to research published in the July 25 early-release issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.

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Risk of Contracting Zika at Rio Olympics Small

TUESDAY, July 26, 2016 (HealthDay News) — Travelers and competitors at the 2016 Olympic Games in Brazil are not likely to contract the Zika virus during their stay or bring it back to their home countries, according to an Ideas and Opinions piece published online July 26 in the Annals of Internal Medicine.

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Up to 1.6 Million Childbearing Women Possibly at Risk for Zika

MONDAY, July 25, 2016 (HealthDay News) — Up to 1.6 million childbearing women in Central and South America may be at risk for infection with the Zika virus by the end of the first phase of the epidemic, according to a letter published online July 25 in Nature Microbiology.

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CDC Updates Guidelines on Sexual Transmission of Zika

MONDAY, July 25, 2016 (HealthDay News) — U.S. health officials on Monday updated their Zika virus guidelines, saying that pregnant women could contract Zika from a sex partner of either gender.

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Arsenic-Contaminated Water Linked to Skin Cancer in U.S.

MONDAY, July 25, 2016 (HealthDay News) — Arsenic-contaminated water, at levels below the 2001 Environmental Protection Agency (EPA) maximum, is associated with skin cancer in U.S. populations, according to a review published online July 15 in the International Journal of Dermatology.

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Gut Microbiome Diversity Lower in Chronic Pelvic Pain Syndrome

MONDAY, July 25, 2016 (HealthDay News) — Gut microbiome diversity is significantly lower in patients with chronic pelvic pain syndrome, with wider clustering, according to a study published in the August issue of The Journal of Urology.

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‘Walking Meetings’ Feasible Strategy for Employee Wellness

MONDAY, July 25, 2016 (HealthDay News) — Converting a single weekly meeting to a walking meeting can help raise work-related physical activity levels of white-collar workers, according to a report published online June 23 in the U.S. Centers for Disease Control and Prevention’s Preventing Chronic Disease.

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Severe Hypoglycemia Linked to Mortality, CVD Events in T1DM

FRIDAY, July 22, 2016 (HealthDay News) — For patients with type 1 diabetes mellitus (T1DM), severe hypoglycemia is associated with increased risk of all-cause mortality and cardiovascular disease (CVD), according to research published online July 6 in Diabetes Care.

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Widely Protective Vaccine Against Chlamydia Appears Promising

FRIDAY, July 22, 2016 (HealthDay News) — A vaccine to help protect against chlamydia is proving to be effective, according to an experimental study published in the July 25 issue of Vaccine.

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Intake of Marine ω-3 PUFAs Tied to Colorectal Cancer Survival

FRIDAY, July 22, 2016 (HealthDay News) — Colorectal cancer (CRC) patients who consume higher amounts of omega-3 polyunsaturated fatty acids (PUFAs), mainly from oily fish, may have better odds of survival, according to a study published online July 19 in Gut.

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Overall Mortality Similar in DCCT/EDIC, General Population

FRIDAY, July 22, 2016 (HealthDay News) — Overall mortality is similar in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study cohort and the general population, according to a study published online July 13 in Diabetes Care.

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Rapid HIV Transmission Seen in Injection Drug Users in Rural U.S.

THURSDAY, July 21, 2016 (HealthDay News) — The U.S. prescription drug abuse epidemic has increased the risk of HIV outbreaks in rural and suburban communities, where up to now the virus has posed little threat, according to a report published in the July 21 issue of the New England Journal of Medicine.

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Imaging Post-Thyroid Cancer Treatment Doesn’t Always Benefit

THURSDAY, July 21, 2016 (HealthDay News) — More imaging tests after treatment does not always lead to an improvement in thyroid cancer patients’ chances of survival, according to a study published online July 20 in The BMJ.

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Health Expenditures Rising for Middle Class, Wealthy

THURSDAY, July 21, 2016 (HealthDay News) — While overall U.S. medical spending growth slowed between 2004 and 2013, expenditures rose for middle- and high-income Americans, according to research published in the July issue of Health Affairs.

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Seropositivity of Meningitis B Vaccine Lower Than Expected

THURSDAY, July 21, 2016 (HealthDay News) — About one-third of Princeton University students given a vaccine to combat a meningitis B outbreak on campus in 2013 didn’t show signs of protection against the infection eight weeks later, according to a study published in the July 21 issue of the New England Journal of Medicine.

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Drug Shows Promise for Genetic Proopiomelanocortin Deficiency

THURSDAY, July 21, 2016 (HealthDay News) — An experimental drug spurred substantial weight loss in patients with proopiomelanocortin (POMC) deficiency, according to a study published in the July 21 issue of the New England Journal of Medicine.

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Failure to Achieve Negative Margin Ups Facial BCC Recurrence

THURSDAY, July 21, 2016 (HealthDay News) — Large tumor diameter, increased age, and failure to achieve negative margin resection at the first surgical appointment are all associated with increased risk of recurrence of facial basal cell carcinoma (BCC), according to a study published online July 15 in the International Journal of Dermatology.

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Possible Local Transmission of Zika Virus in Florida

WEDNESDAY, July 20, 2016 (HealthDay News) — Florida health officials are investigating what could be the first case of locally transmitted Zika virus infection in the continental United States.

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Diabetes Rates for U.S. Teens Higher Than Previously Reported

WEDNESDAY, July 20, 2016 (HealthDay News) — More American teens have diabetes or prediabetes than previously thought, and many don’t know they have the condition, according to a research letter published in the July 19 issue of the Journal of the American Medical Association.

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Medicare Spending Up for Decedents Versus Survivors

WEDNESDAY, July 20, 2016 (HealthDay News) — Medicare per capita spending was much higher for beneficiaries who died during 2014 than for those who survived the entire year, according to a report published by the Kaiser Family Foundation.

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Osteoporosis Treatment-Linked Changes in BMD ID Fracture Risk

WEDNESDAY, July 20, 2016 (HealthDay News) — For women initiating osteoporosis treatment, treatment-related changes in total hip bone mineral density (BMD) are associated with fracture risk, according to a study published online July 19 in the Annals of Internal Medicine.

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IVF Treatment Does Not Appear to Increase Breast Cancer Risk

WEDNESDAY, July 20, 2016 (HealthDay News) — Women who undergo in vitro fertilization (IVF) are not at increased risk of breast cancer, according to a study published in the July 19 issue of the Journal of the American Medical Association.

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Metastatic Prostate Cancer Cases Increasing in the United States

TUESDAY, July 19, 2016 (HealthDay News) — New cases of metastatic prostate cancer in the United States have increased 72 percent in the past decade, according to a study published online July 19 in Prostate Cancer and Prostatic Diseases.

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Global Fight Against HIV Remains Challenging

TUESDAY, July 19, 2016 (HealthDay News) — The number of HIV/AIDS deaths worldwide each year has fallen since peaking in 2005, but the number of new HIV infections is up in 74 countries, according to a study published online July 19 in The Lancet HIV to coincide with the 21st International AIDS Conference, held from July 18 to 22 in Durban, South Africa.

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X-Rays Have Low Diagnostic Yield for Pulmonary Metastases

TUESDAY, July 19, 2016 (HealthDay News) — For patients treated for T1a renal cell carcinoma, chest X-rays have low diagnostic yield for detecting pulmonary metastases, according to a study published in the August issue of The Journal of Urology.

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Abnormal Uterine Bleeding Can Signal Hematologic Cancer

TUESDAY, July 19, 2016 (HealthDay News) — Among women presenting with a chief complaint of abnormal uterine bleeding (AUB), there is an estimated incidence of hematologic cancer of 3.6 cases per 1,000 women, according to research published in the August issue of Obstetrics & Gynecology.

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Grindr Feasible for Distributing HIV Self-Tests to High-Risk MSM

TUESDAY, July 19, 2016 (HealthDay News) — The social networking app Grindr is feasible for distributing HIV self-test kits to men who have sex with men (MSM), according to a study published online recently in Sexual Health.

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Labor Compensation, Purchased Goods, Service Biggest Spends

TUESDAY, July 19, 2016 (HealthDay News) — Labor compensation remains the single largest contributor to costs among physicians’ offices, hospitals, and outpatient care centers, according to a report published in the July issue of Health Affairs.

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Proinsulin-to-C-Peptide Ratio Linked to Progression to T1DM

TUESDAY, July 19, 2016 (HealthDay News) — Elevation in the serum proinsulin-to-C-peptide (PI:C) ratio is associated with progression to type 1 diabetes, according to a study published online July 6 in Diabetes Care.

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U.S. Zika Patient in Utah Apparently Infected Caregiver

MONDAY, July 18, 2016 (HealthDay News) — On Monday, U.S. health officials said they were trying to determine how a now-deceased elderly Utah man who had Zika managed to infect a family caregiver.

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Burnout Can Have Acute Personal, Professional Consequences

MONDAY, July 18, 2016 (HealthDay News) — Stress and burnout are increasingly prevalent among physicians, with serious personal and professional consequences, according to a report published in Medical Economics.

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Baseline ALT, AST Frequently Assessed With Statin Initiation

MONDAY, July 18, 2016 (HealthDay News) — Most Medicare fee-for-service beneficiaries with dyslipidemia who initiate statins undergo baseline alanine aminotransferase (ALT) and aspartate aminotransferase (AST) testing, according to a study published in the Aug. 1 issue of The American Journal of Cardiology.

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MRI Feasible for Predicting Prostate CA in Unselected Sample

MONDAY, July 18, 2016 (HealthDay News) — Prostate multiparametric magnetic resonance imaging (MRI) is feasible for predicting prostate cancer in an unselected sample of the general population, according to a study published in the August issue of The Journal of Urology.

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CDC Reports First Female-to-Male Sexual Transmission of Zika

FRIDAY, July 15, 2016 (HealthDay News) — A New York City woman who became infected with the Zika virus on a trip outside the United States passed the infection to her boyfriend during sex, according to research published in the July 15 early-release issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.

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Growth in U.S. Health Spending Set to Average 5.8 Percent

FRIDAY, July 15, 2016 (HealthDay News) — Growth in U.S. health spending is expected to average 5.8 percent for 2015 to 2025, according to a study published in the July issue of Health Affairs.

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Antibiotic-Resistant Gonorrhea on the Rise in the United States

FRIDAY, July 15, 2016 (HealthDay News) — Antibiotic-resistant cases of gonorrhea have more than quadrupled in the United States, according to research published in the July 15 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.

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Increase in Acute Synthetic Cannabinoid Poisonings

FRIDAY, July 15, 2016 (HealthDay News) — Synthetic cannabinoids are sending increasing numbers of U.S. users to hospitals, according to research published in the July 15 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.

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Patient Satisfaction High for Mohs Micrographic Surgery

FRIDAY, July 15, 2016 (HealthDay News) — For patients with skin cancer, Mohs micrographic surgery (MMS) is safe and well tolerated, with high levels of patient satisfaction, according to a research letter published online July 5 in the British Journal of Dermatology.

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Review: Plant-Based Diets Tied to Improved Inflammatory Profiles

FRIDAY, July 15, 2016 (HealthDay News) — Plant-based diets are associated with improvement in obesity-related inflammatory biomarker profiles, including decreases in C-reactive protein and interleukin-6 levels, according to a review published online July 13 in Obesity Reviews.

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Diet-Induced Weight Loss May Help Prevent CA in Obese Women

THURSDAY, July 14, 2016 (HealthDay News) — Overweight and obese women who lose weight via calorie restriction, with or without exercise, may lower their odds of developing cancer as their levels of proteins tied to angiogenesis drop, according to a study published online July 15 in Cancer Research.

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Supreme Court Ruling Could Impact Med School Admissions

THURSDAY, July 14, 2016 (HealthDay News) — The U.S. Supreme Court’s ruling upholding the University of Texas at Austin’s consideration of race and ethnicity in college admissions has implications for medical schools, according to the American Medical Association (AMA).

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Effects of APOE Gene May Be Apparent in Childhood

THURSDAY, July 14, 2016 (HealthDay News) — Variations in the APOE gene may start to show effects on brain structure and mental acuity as early as preschool, according to a study published online July 13 in Neurology.

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Differences in Salary for Male, Female Faculty Physicians

WEDNESDAY, July 13, 2016 (HealthDay News) — For physicians with faculty appointments at 24 U.S. public medical schools there are significant salary differences between men and women, even after adjustment for confounding variables, according to a study published online July 11 in JAMA Internal Medicine.

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One Week of Bed Rest Lowers Muscle Mass, Insulin Sensitivity

WEDNESDAY, July 13, 2016 (HealthDay News) — One week of bed rest is associated with a substantial reduction in skeletal muscle mass and decreased whole-body insulin sensitivity, according to a study published online June 29 in Diabetes.

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Follow-Up of Colorectal CA Screens Lacking in Older Patients

WEDNESDAY, July 13, 2016 (HealthDay News) — A considerable proportion of older patients are not up-to-date with colorectal cancer screening and do not receive timely follow-up of abnormal fecal blood tests, according to a study published online June 22 in the American Journal of Preventive Medicine.

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Small HIV Infection Risk in Condomless Sex With Use of ART

WEDNESDAY, July 13, 2016 (HealthDay News) — HIV transmission is highly unlikely among heterosexual couples who have sex without condoms when one partner carries the virus but takes antiretroviral therapy, according to a study published in the July 12 issue of the Journal of the American Medical Association, a theme issue on HIV/AIDS.

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Post-MI Heart Failure Linked to Increased Cancer Risk

WEDNESDAY, July 13, 2016 (HealthDay News) — Patients who develop heart failure after myocardial infarction may also face a higher risk of cancer, according to a study published in the July 19 issue of the Journal of the American College of Cardiology.

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Second U.S. Case of Bacteria Resistant to Colistin

TUESDAY, July 12, 2016 (HealthDay News) — Scientists have identified a second patient in the United States who was infected with a bacteria that is resistant to an antibiotic of last resort. The findings were published online July 11 in Antimicrobial Agents and Chemotherapy.

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Traumatic Brain Injury Tied to Risk of Parkinson’s Disease

TUESDAY, July 12, 2016 (HealthDay News) — A traumatic brain injury (TBI) with loss of consciousness may increase the risk of developing Parkinson’s disease, according to research published online July 11 in JAMA Neurology.

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Utah Resident Is First Zika-Linked Death in Continental U.S.

MONDAY, July 11, 2016 (HealthDay News) — An elderly resident of Utah who died at the end of June is the first fatality in the continental United States linked to infection with the Zika virus, local health officials said Friday.

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Approval of First HPV Test for Use With SurePath Preservative Fluid

MONDAY, July 11, 2016 (HealthDay News) — The U.S. Food and Drug Administration has approved Roche’s cobas HPV Test as the first diagnostic to be used with cervical cells obtained for a Pap test and collected in SurePath Preservative Fluid.

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Emetine Shows Promise for Human Cytomegalovirus Infection

MONDAY, July 11, 2016 (HealthDay News) — Emetine may represent a therapeutic option for human cytomegalovirus (HCMV) infection, according to a study published in the June issue of PLOS Pathogens.

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Overall Survival Up With Surgical Treatment in T3 Glottic SCC

MONDAY, July 11, 2016 (HealthDay News) — Patients with T3 glottic squamous cell carcinoma (SCC) have improved overall survival (OS) with surgical treatment versus nonsurgical management, according to a study published online July 7 in JAMA Otolaryngology-Head & Neck Surgery.

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Second, Unrelated Malignancies Strike 1 in 12 Cancer Patients

FRIDAY, July 8, 2016 (HealthDay News) — A new study indicates that 8 percent of patients — or one in 12 — already diagnosed with one form of cancer will develop a second unrelated malignancy. The findings were published online July 5 in Cancer.

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Retinoblastoma Mortality Up With Eye-Preserving Radiotherapy

FRIDAY, July 8, 2016 (HealthDay News) — Short-term survival of heritable retinoblastoma is high, but long-term mortality remains a challenge, according to a study published online July 5 in the Journal of Clinical Oncology.

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VA Appealing to Physicians to Join Agency

FRIDAY, July 6, 2016 (HealthDay News) — The U.S. Department of Veterans Affairs (VA) is appealing to physicians to join the agency as part of its recovery from a 2014 scandal linked to excessive wait times, according to a report published by the American Medical Association.

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Blood Test Might Help Diagnose Viral Versus Bacterial Infection

FRIDAY, July 8, 2016 (HealthDay News) — A blood test based on gene responses may help differentiate between bacterial and viral infections, according to a study published July 6 in Science Translational Medicine.

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Reduced Microbiome Diversity in Myalgic Encephalopathy/CFS

FRIDAY, July 8, 2016 (HealthDay News) — Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have reduced diversity and altered composition of the gut microbiome, according to a study published online June 23 in Microbiome.

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CDC: Majority of HPV-Linked Cancers Are Preventable

FRIDAY, July 8, 2016 (HealthDay News) — The majority of cancers linked to human papillomavirus (HPV) are preventable, according to a report published in the July 8 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.

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Circulating Tumor DNA May Help Predict Colon CA Recurrence

FRIDAY, July 8, 2016 (HealthDay News) — Detection of circulating tumor DNA (ctDNA) after resection of stage II colon cancer may identify patients at increased risk of recurrence, according to a study published July 6 in Science Translational Medicine.

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Metabolomics Signature Can Predict GDM to T2DM Transition

THURSDAY, June 30, 2016 (HealthDay News) — A metabolomics signature can predict the transition from gestational diabetes mellitus (GDM) to type 2 diabetes (T2D), according to a study published online June 23 in Diabetes.

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Risk Score Could Help ID Alzheimer’s Risk in Young Adults

THURSDAY, July 7, 2016 (HealthDay News) — A genetic test may one day be able to predict the risk for Alzheimer’s disease (AD) in young adults, according to a study published online July 6 in Neurology.

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Toys in Waiting Room May Be Source of Infection

THURSDAY, July 7, 2016 (HealthDay News) — Toys help spread the flu and other viruses because germs can survive on plastic surfaces for 24 hours or more, according to a study published recently in The Pediatric Infectious Disease Journal.

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DNA-Repair Gene Mutations ID’d in Metastatic Prostate Cancer

THURSDAY, July 7, 2016 (HealthDay News) — For men with metastatic prostate cancer, the incidence of germline mutations in genes associated with DNA-repair processes is 11.8 percent, according to a study published online July 6 in The New England Journal of Medicine.

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Lab-Established Diagnosis Key for Persistent Diarrhea

THURSDAY, July 7, 2016 (HealthDay News) — Persistent diarrhea is typically caused by parasites or bacteria and requires accurate diagnosis in order to determine appropriate treatment, according to a review published online June 28 in the Journal of the American Medical Association.

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1997 to 2011 Saw Almost 50 Percent Drop in ED Death Rates

THURSDAY, July 7, 2016 (HealthDay News) — From 1997 to 2011 there was a 48 percent reduction in emergency department (ED) mortality rates, according to a study published online July 6 in Health Affairs.

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Arthritis, Arthritis-Attributable Activity Limitations Likely to Rise

THURSDAY, July 7, 2016 (HealthDay News) — The prevalence of arthritis and arthritis-attributable activity limitation is projected to increase in U.S. adults by 2040, according to a study published online June 24 in Arthritis & Rheumatology.

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Candida auris Causing Healthcare-Associated Infections

WEDNESDAY, July 6, 2016 (HealthDay News) — The emerging multidrug-resistant yeast Candida auris is causing invasive healthcare-associated infections with high mortality internationally, according to a clinical alert to U.S. healthcare facilities published by the U.S. Centers for Disease Control and Prevention.

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Laser Tx of Pigmented Lesions May Obscure Melanoma Diagnosis

WEDNESDAY, July 6, 2016 (HealthDay News) — Laser treatment of pigmented lesions can complicate the diagnosis of melanoma and potentially lead to a delay in diagnosis, according to a study published online June 27 in The Journal of Dermatology.

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Euthanasia, Doc-Assisted Suicide Increasingly Being Legalized

WEDNESDAY, July 6, 2016 (HealthDay News) — Euthanasia and physician-assisted suicide are increasingly being legalized, but their use remains rare, according to a special communication published online July 5 in the Journal of the American Medical Association.

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Familial Clustering of Staphylococcus aureus Found

WEDNESDAY, July 6, 2016 (HealthDay News) — History of Staphylococcus aureus bacteremia in a first-degree relative, especially a sibling, is associated with an increased rate of the disease, according to a study published online July 4 in the Annals of Internal Medicine.

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Gadolinium Exposure From MRI Not Linked to Parkinsonism

WEDNESDAY, July 6, 2016 (HealthDay News) — Gadolinium exposure seems not to be associated with parkinsonism, according to a research letter published online July 5 in the Journal of the American Medical Association.

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Genetic Risk Score Impact on BMI Varies Across Birth Cohorts

WEDNESDAY, July 6, 2016 (HealthDay News) — The magnitude of the association between a multilocus genetic risk score for body mass index (GRS-BMI) and BMI is larger for individuals born in later birth cohorts, according to a study published online July 5 in the Journal of the American Medical Association.

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Risk of Noncervical Anogenital Cancer Up With History of CIN2/3

WEDNESDAY, July 6, 2016 (HealthDay News) — Women with a history of cervical intraepithelial neoplasia (CIN)2 or CIN3 have increased risks of subsequent development of anal, vulvar, and vaginal cancers, according to a study published online June 29 in Cancer Epidemiology, Biomarkers & Prevention.

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Many Clinical Trials Are Not Listed in Data-Sharing Repository

WEDNESDAY, July 6, 2016 (HealthDay News) — Only about half of trials registered at ClinicalTrials.gov are listed in the largest data-sharing repository, according to a research letter published online June 28 in the Journal of the American Medical Association.

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CVD Risks Way Up in Familial Hypercholesterolemia

TUESDAY, July 5, 2016 (HealthDay News) — Patients with heterozygous familial hypercholesterolemia (FH) have a significantly increased risk for coronary heart disease (CHD) and atherosclerotic cardiovascular disease (ASCVD), according to research published online June 29 in Circulation.

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Two-Stage Screening Could Be Cost-Effective for Trisomy

TUESDAY, July 5, 2016 (HealthDay News) — Limiting first trimester screening (FTS) by cell-free fetal (cff) DNA to only patients in certain risk categories may be a feasible cost-containing strategy, according to a study published online June 27 in the Journal of Evaluation in Clinical Practice.

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Fish, Chicken Meat Are Cross-Reactive Foods

TUESDAY, July 5, 2016 (HealthDay News) — Fish and chicken meat are cross-reactive, involving three allergens, according to a study published online June 27 in Allergy.

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Elevated Risk of Death for Osteogenesis Imperfecta

TUESDAY, July 5, 2016 (HealthDay News) — Patients with osteogenesis imperfecta (OI) have an elevated risk of death, according to a study published online June 27 in the Journal of Bone and Mineral Research.

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U.S. Cancer Survivors Aging, Battling Other Chronic Disease

FRIDAY, July 1, 2016 (HealthDay News) — In 2016, nearly 62 percent of almost 16 million cancer survivors are aged 65 or older; and, by 2040, an estimated 73 percent of 26 million cancer survivors will be 65 or older, according to a report published in the July 1 issue of Cancer Epidemiology, Biomarkers & Prevention.

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Knowledge of CT Risks Varies Among Health Care Providers

FRIDAY, July 1, 2016 (HealthDay News) — Radiologists and technologists have better knowledge about the risks associated with medical imaging examinations than referring physicians, according to a study published online June 22 in the Journal of Medical Imaging and Radiation Sciences.

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Hundreds of U.S. Clinics Sell Unapproved Stem Cell ‘Therapies’

FRIDAY, July 1, 2016 (HealthDay News) — Hundreds of clinics across the United States are marketing unapproved stem cell treatments for conditions ranging from aging skin to spinal cord injuries, according to a study published online June 30 in Cell Stem Cell.

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Extended-Spectrum Antibiotics No Benefit for Pediatric Appendicitis

FRIDAY, July 1, 2016 (HealthDay News) — For children diagnosed with appendicitis undergoing appendectomy, extended-spectrum antibiotics seem to offer no advantage over narrower-spectrum agents, according to a study published online June 28 in Pediatrics.

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