Home Cardiology Growth Differentiation Factor 15 Levels Linked to CAD

Growth Differentiation Factor 15 Levels Linked to CAD

Serum levels significantly increased in coronary artery disease patients versus healthy controls

FRIDAY, March 25, 2016 (HealthDay News) — Serum growth differentiation factor 15 (GDF-15) levels are associated with coronary artery disease (CAD), according to a study published online March 21 in Cardiovascular Therapeutics.

Xia Wang, from the Nanjing Medical University in China, and colleagues examined serum GDF-15 levels and predictive values in patients with CAD. The enzyme-linked immunosorbent assay was used to measure serum levels of GDF-15 in 105 CAD patients and 96 healthy controls. CAD severity was assessed with Gensini scores; the correlations between serum GDF-15 levels and Gensini scores were assessed.

The researchers found that serum GDF-15 levels were significantly increased in patients with CAD versus the healthy group (P < 0.001). There was a positive correlation between GDF-15 and Gensini score (r = 0.85; P < 0.001). The area under the receiver operating characteristic curve analysis result was 0.96 (P < 0.001); serum GDF-15 level had sensitivity and specificity of 80.0 and 91.7 percent, respectively, for predicting CAD.

“These data suggested that increased GDF-15 levels were positively associated with CAD, and GDF-15 might be a useful adjunct in discriminating CAD,” the authors write.

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