Frailty linked to subsequent risk of all-cause mortality after adjustment for confounders
TUESDAY, June 7, 2016 (HealthDay News) — Among young adult hematopoietic cell transplantation (HCT) survivors, the prevalence of frailty exceeds 8 percent and is associated with increased risk of mortality, according to a study published online June 2 in JAMA Oncology.
Mukta Arora, M.D., from the University of Minnesota in Minneapolis, and colleagues determined the prevalence of frailty in young adult HCT patients and siblings in a cohort study. Data were included for 998 HCT survivors who underwent transplant procedures between 1974 and 1998 and 297 frequency-matched siblings.
The researchers found that among young adult HCT patients the prevalence of frailty exceeded 8 percent. Compared with their siblings, HCT survivors were 8.4 times more likely to be frail (P = 0.003). Among HCT recipients, the risk of frailty was increased for allogeneic HCT recipients with chronic graft-versus-host disease (GvHD) or resolved chronic GvHD compared with autologous HCT (odds ratios, 15.02 and 2.7, respectively). For HCT recipients with and without frailty, the cumulative incidence of subsequent all-cause mortality was 39.3 and 14.7 percent, respectively, at 10 years (P < 0.001). After adjustment for relevant prognosticators, frailty correlated with a 2.76-fold increased risk of subsequent mortality (P < 0.001).
“The prevalence of frailty among young-adult HCT survivors approaches that seen in the elderly general population,” the authors write. “This study identifies vulnerable populations needing close monitoring to anticipate and manage morbidity and prevent mortality.”
Copyright © 2016 HealthDay. All rights reserved.