Home Gastroenterology Fecal Transplants Deemed Successful in C. difficile Tx

Fecal Transplants Deemed Successful in C. difficile Tx

Fecal matter is collected from donor, purified, mixed with saline solution and transferred to patient

MONDAY, March 30, 2015 (HealthDay News) — Fecal transplants, using stool from a donor, have been successful at treating Clostridium difficile infection, researchers report online March 30 in Microbiome.

The study included 14 people who had recurring C. difficile infections. Four received fecal transplants. The healthy changes in the patients’ intestinal bacterial populations (“microbiome”) were sustained for up to 21 weeks after transplant, according to the report. “Our study shows that there are both short- and long-term changes in the fecal microbiome following transplantation,” study author Michael Sadowsky, Ph.D., director of the University of Minnesota’s BioTechnology Institute in St. Paul, said in a journal news release.

“The diversity and types of microbes present fall into a cloud of possibilities represented by those of ‘normal fecal microbiota.’ While we have many similarities in fecal microbiota amongst humans in general, there are individual differences that make us all unique, but do not affect apparent gut functioning,” he explained.

The study could have implications for the regulation of fecal transplants in the United States, the authors suggested. The U.S. Food and Drug Administration considers fecal transplants to be a drug and has said standardization will be important. However, the diversity of normal fecal bacteria in both donors and recipients suggests that this approach to regulation will not work for fecal transplants, the investigators said in the news release.

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