Association attenuated when longer hospital length of stay is accounted for
MONDAY, Aug. 29, 2016 (HealthDay News) — Preeclampsia before 34 weeks may be associated with increased risk of hemangioma, although the correlation is attenuated when longer hospital length of stay is accounted for, according to a study published online Aug. 12 in the British Journal of Dermatology.
Nathalie Auger, M.D., from the Institute national de santé publique du Québec in Montreal, and colleagues examined the correlation between variants of preeclampsia and the risk of infantile hemangioma in a retrospective cohort study. Data were included for 14,240 neonates with and 1,930,564 without hemangioma before discharge.
The researchers found that the prevalence of any hemangioma was higher for preeclampsia (81.3 per 10,000) than for no preeclampsia (72.9 per 10,000); after adjustment for maternal characteristics, the prevalence ratio (PR) was 1.15. Preeclampsia with onset before 34 weeks was associated with cutaneous, noncutaneous, and unspecified hemangioma (PRs, 2.32, 3.66, and 2.49, respectively). Once long neonatal length of hospital stay was accounted for, the association between early onset preeclampsia and hemangioma was attenuated. There was no correlation with late preeclampsia (after 34 weeks); correlations were weaker for other preeclampsia variants, including severe preeclampsia and preeclampsia with low birth weight.
“Early onset preeclampsia is associated with increased risk of hemangioma at birth, but detection bias due to longer hospital stays and closer follow-up may be part of the reason,” the authors write.
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