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Decreased Clot Retraction Rate in Asthma

Reduction in CRR, fibrinolysis rate, FEV1 in asthma versus healthy controls; increase in clot density

FRIDAY, Nov. 4, 2016 (HealthDay News) — Clot retraction rate (CRR) and fibrinolysis rate (FR) are reduced in steroid-naive asthma, according to a study published online Oct. 14 in Allergy.

Maria M. Tomasiak-Lozowska, M.D., Ph.D., from the Medical University of Bialystok in Poland, and colleagues assessed CRR, FR, clot density (CD), plasma levels of plasminogen activator inhibitor (PAI-1) and factor XIII (FXIII), nitric oxide (NO) in exhaled breath (FENO), spirometry (forced expiratory volume in one second [FEV1]), and eosinophil count (EOS) in allergic, steroid-naive asthma patients (36 patients) and healthy controls (34 patients).

The researchers found that, compared with controls, patients with asthma had significant reductions in CRR, FR, and FEV1, and increases in FENO, EOS, PAI-1, FXIII, and CD (all P < 0.001). There was a negative correlation for FR with CD, FXIII, PAI-1, FENO, and EOS, and a positive correlation with FEV1. A positive correlation was seen for FXIII with CD. A negative correlation was seen for CRR with FENO and a positive correlation with FEV1 (all P < 0.001).

“These novel findings suggest that asthma itself is associated with decreased CRR and reduced fibrinolytic potential resulting from alterations in clot architecture and elevated levels of plasma FXIII and PAI-1,” the authors write.

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