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Macrophage cyclooxygenase-2 deletion is associated with progression of diabetic nephropathy

Macrophage COX-2 Prevents Diabetic Nephropathy Progression

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Mice with COX-2 deletion in hematopoietic cells or macrophages have severe DN vs WT diabetic mice
Increased body mass index may have a moderate effect on hand arthritis

Meta-Analysis Links Increased BMI, Hand Osteoarthritis

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Weak but significant effect seen on risk of radiographic hand osteoarthritis
Patients with type 1 diabetes diagnosed at age 15 to 27 years have low cumulative incidence of end-stage renal disease and increased mortality during long-term follow-up

Cumulative Incidence of ESRD Low in Patients With Type 1 DM

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Cumulative incidence of ESRD 4.6 percent during 30 years' follow-up for those diagnosed at age 15 to 27
Genetic variations correlate with mortality in the elderly

Genetic Mortality Risk Can Be Attenuated by Lifestyle

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Mortality up to 64 percent lower for those with low-risk lifestyle profile, independent of genetic risk
An adapted clinical practice guideline

Guideline Adapted for Surgical Antimicrobial Prophylaxis

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ADAPTE methodology was used to produce an adapted clinical practice guideline for SAP
BACH2 is a major risk locus for Addison's disease

BACH2 Identified As Risk Locus for Addison’s Disease

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Extended exome capture array shows BACH2 correlates with Addison's disease development
In high-risk fetuses

Isolated Chorionic Bump Tied to Fetal Aneuploidy

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Elevated odds for those with isolated chorionic bump and increased first-trimester aneuploidy risk
Low vitamin D levels may increase the risk of bladder cancer

Bladder Cancer Risk Correlates With Low Serum Vitamin D

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Researchers find that bladder epithelial cells activate and respond to vitamin D
For patients with type 1 diabetes

PCSK9, LDL-C Link Only Seen for Patients With Highest HbA1c

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In patients with type 1 diabetes, correlation only seen for those in the highest tertile of HbA1c
Ocular syphilis has been identified in jurisdictions in the United States

Ocular Syphilis Cases May Be Increasing in United States

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Among total syphilis surveillance cases in eight jurisdictions, 0.65 percent indicated ocular symptoms