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Heterozygous HTRA1 mutations may play a role in familial cerebral small vessel disease

HTRA1 Mutations Tied to Cerebral Small Vessel Disease

Correlation seen between mutations and MRI brain findings
There is a non-linear association between caloric load and reward

Taste, Calories Affect Metabolic Response to Sugared Beverages

Metabolic responses up for lower calorie beverages, and when sweetness is proportional to caloric load
For humans and mice

Disruption of NAD Synthesis Tied to Congenital Malformations

Patients with congenital mutations have lower levels of circulating nicotinamide adenine dinucleotide
A biomarker-based model provides a new tool for the prediction of cardiovascular death in patients with stable coronary heart disease

New Model Predicts Mortality in Stable Coronary Heart Disease

Model uses age, biomarkers, clinical variables to predict cardiovascular death
Sleep-disordered breathing is associated with cognitive deficits

Sleep-Disordered Breathing Linked to Cognitive Dysfunction

Hypoxemia and sleepiness associated with cognitive deficits, with strongest effect in APOE-ε4 carriers
Diabetes in infancy has different characteristics depending on mutation subtype

Characteristics of Diabetes in Infancy Explored

Overall frequency of diabetic ketoacidosis 66.2 percent; odds increase with age at diagnosis
For patients newly diagnosed with type 1 diabetes

Peptide Immunotx Well Tolerated in New-Onset Type 1 Diabetes

No decline in C-peptide with peptide immunotherapy; no change in insulin use over 12 months
For patients after allogeneic hematopoietic stem cell transplant

Azithromycin Tied to Poor Airflow Decline-Free Survival After HSCT

Worse airflow decline-free survival than placebo after allogeneic hematopoietic stem cell transplant
Single measures of viral load can overestimate how many individuals with HIV infection have viral suppression

Single Measures of Viral Load May Overestimate HIV Suppression

Overall, 57.3 percent had suppressed load in most recent test; 47.6 percent had durable suppression
Flatter diurnal cortisol slopes correlate with poorer health in 10 of 12 subtypes of emotional and physical health outcomes examined

Flatter Diurnal Cortisol Slopes Linked to Poorer Health Outcomes

Flatter diurnal cortisol slopes tied to poorer health in 10 of 12 subtypes of emotional, physical health