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Reproductive factors

Higher CVD Risk With Early Menarche, Menopause

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Various reproductive factors linked to CVD risk; number of children tied to CVD risk for both genders
Elevation in white blood cell BRCA1 promoter methylation is associated with high-grade serous ovarian cancer

BRCA1 Promoter Methylation Tied to High-Grade Serous Ovarian CA

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Elevated normal tissue BRCA1 promoter methylation associated with high-grade serous ovarian CA risk
Patients with myeloproliferative neoplasms (MPNs) have increased risk of arterial thrombosis and venous thrombosis across all age groups and MPN subtypes

Increased Risk of Thrombosis in Myeloproliferative Neoplasms

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Higher rates of thrombosis compared to matched controls; risk highest at and soon after diagnosis
Hepatic fat accumulation may play a causal role in chronic liver disease

Hepatic Fat Accumulation May Have Causal Role in Liver Disease

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Impact of genetic variants on liver damage proportional to effect on hepatic fat accumulation
Acetaminophen use in pregnancy is associated with language delay among girls

Acetaminophen Use in Pregnancy Linked to Language Delay

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Number of APAP tablets, urinary APAP concentration linked to increased odds of language delay in girls
Improving adherence to healthy dietary patterns may help reduce the genetic association with weight gain

Adherence to Healthy Diet May Cut Effects of Genetics on Obesity

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Long-term, improved diet quality benefits weight control in those with high genetic risk of obesity
Children with psoriasis have an increased risk of comorbidities compared to children without psoriasis

Psoriasis Is Independent Risk Factor for Comorbidity in Children

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Those with psoriasis at higher risk for diabetes, liver disease, elevated lipid levels independent of obesity
The contributions of screening and treatment to decreases in breast cancer mortality vary by molecular subtype

Screening, Therapy Effect Varies by Breast CA Molecular Subtype

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Reductions in breast cancer mortality linked to screening and treatment, but associations vary
The U.S. Preventive Services Task Force has concluded that the current evidence is insufficient to assess the balance of benefits and harms of screening for adolescent idiopathic scoliosis in children and adolescents aged 10 to 18 years. The recommendation statement has been published in the Jan. 9 issue of the Journal of the American Medical Association.

USPSTF Questions Adolescent Idiopathic Scoliosis Screening

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Finds insufficient evidence on balance of benefits and harms of screening asymptomatic 10- to 18-year-olds
For young adults without known risk factors

HIV Screening Most Optimal at 25 Years of Age If No Risk Factors

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Simulation favors screening at 25 for adolescents, young adults without identifiable HIV risk factors