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Pathology

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A newly identified genetic risk variant is associated with comorbid alcohol dependence and major depression in African Americans

Locus ID’d That Links Comorbid Alcohol Dependence, Depression

Robust association identified for SEMA3A locus in African American participants in two samples
Direct-to-consumer genetic testing raises unique concerns and considerations

Concerns Surround Use of Direct-to-Consumer Genetic Testing

Issues include limited knowledge about available tests, difficulty interpreting results, lack of oversight
Higher HER3 expression is associated with improved survival with the addition of panitumumab treatment for patients with RAS wild-type advanced colorectal cancer

HER3 Linked to Improved Survival With Panitumumab

Addition of panitumumab to irinotecan tied to improved survival in RAS wt advanced colorectal CA
For patients with chronic kidney disease

Vitamin D Supplements Improve Markers of Bone Turnover in CKD

Cholecalciferol can also correct vitamin D deficiency in patients with chronic kidney disease
Critically injured patients develop changes in the composition of the gut microbiome within 72 hours

Alterations in Gut Microbiome Noted Within 72 Hours of Injury

Significant changes in phylogenetic composition and taxon relative abundance in critically injured patients
Undiagnosed diabetes accounts for a relatively small proportion of the total diabetes population in the United States

Undiagnosed Diabetes Accounts for Small Portion of Diabetes

Undiagnosed cases fell from 16.3 to 10.9 percent of total diabetes from 1988-1994 to 2011-2014
Among patients with acute heart failure

Diabetes Tied to Worse Outcomes in Heart Failure Patients

However, long-term prognosis has improved in heart failure patients regardless of diabetes status
Leptin appears to mediate the correlation between weight suppression and duration of illness in bulimia nervosa-syndrome

Researchers Study Mediating Role of Leptin in Bulimia

Model in which longer illness duration contributed to leptin via weight suppression not supported

September 2017 Briefing – Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for September 2017. This roundup includes the latest...
There appears to be an inverse association between coffee intake and protein markers linked to cardiovascular disease

Inverse Association Seen for Coffee Drinking, Markers of CVD

Leptin, chitinase-3-like protein 1 are linked to CVD, may decrease with higher coffee intake