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A clinical trial to test an experimental antiviral drug's effectiveness against the new coronavirus will be conducted in China as it battles a coronavirus outbreak there.

Experimental Antiviral Drug to Be Tested Against New Coronavirus

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Trial to be conducted in the central Chinese city of Wuhan, the epicenter of the outbreak
Altering the default settings in the electronic medical record can influence the quantity of opioids prescribed in an emergency department setting

Altering Default Settings in EHR Influences Opioid Prescribing

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Lower default was associated with lower number of pills prescribed in eight of 15 pairwise comparisons
In a clinical guideline published online Feb. 4 in the Annals of Internal Medicine

U.S. Adult Immunization Schedule Updated for 2020

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Shared clinical decision making recommended for HPV in adults age 27 to 45 considered likely to benefit
Multiple major cities in China are estimated to have imported cases of 2019 novel coronavirus and epidemics are estimated to be growing exponentially in those cities

Spread of 2019 Novel Coronavirus Outbreak Estimated

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By Jan. 25, 2020, 75,815 individuals had been infected in Wuhan; epidemic doubling time 6.4 days
Methodological problems and study limitations for trials of the human papillomavirus vaccine create uncertainty about its ability to prevent cervical cancer in the long term

Whether HPV Vaccination Will Prevent Cervical Cancer Unclear

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Review highlights limitations of trial design; additional research needed to address uncertainties
The Cambridge Multimorbidity Score is robust for predicting key outcomes

Cambridge Multimorbidity Score Robust for Predicting Outcomes

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Model performed better than Charlson Comorbidity Index for predicting consultations, admissions
In a descriptive study published online Jan. 29 in The Lancet

Clinical Characteristics ID’d for 99 Patients With 2019 Novel Coronavirus

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Second study shows 2019-nCoV closely related to bat-derived SARS-like coronaviruses, with 88 percent identity
There are steep incidence increases in colorectal cancer from age 49 to 50 years

Steep Increase Seen in Incidence of CRC From Age 49 to 50 Years

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Increases seen across the U.S., in men and women, in whites and blacks, for colon and rectal cancers
Depression and anxiety are common in patients with rheumatoid arthritis

Mood Disorders Common With Rheumatoid Arthritis

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More than one in eight patients has depression and one in seven has anxiety
Exposure to controlled-release hydromorphone

Hydromorphone-CR Exposure Ups Heart Infection Risk in PWID

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Rates of infective endocarditis increased among PWID exposed to controlled-release hydromorphone