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Hematology and Oncology

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Scientists who discovered that pancreatic cancer is at least four separate diseases say their findings could lead to improved treatments for the disease.

Researchers Say Pancreatic Cancer Is Four Separate Diseases

Findings may lead to better therapies, team says
For men with localized prostate cancer undergoing radical prostatectomy

Lower 25-OH D Tied to Adverse Pathology in Full Prostatectomy

Insufficiency/deficiency of serum 25-OH D linked to increased odds of adverse pathology
Intralesional cryosurgery is feasible for treating basal cell carcinoma of the lower extremities in elderly patients

Intralesional Cryosurgery Feasible for BCC in Elderly

Study shows tumor destruction for eight patients with 10 nodular or superficial BCCs on lower limbs
Use of vaginal estrogen should be carefully considered by women with a history of estrogen-dependent breast cancer

ACOG: Vaginal Estrogen Can Be Used for Breast Cancer Survivors

Decision to use vaginal estrogen should be made with oncologist, after consideration of data
An initiative to employ indication-specific computed tomography protocols and adjustment of scan parameters to decrease radiation exposure still delivers an acceptable level of diagnostic imaging quality

Cutting Radiation Exposure Still Yields Acceptable CT Quality

Image quality decreased but was still acceptable in most cases studied
Recommendations have been developed for colorectal cancer screening in primary care. The guidelines were published online Feb. 22 in CMAJ

Recommendations Developed for CRC Screening in Primary Care

Screening with gFOBT or flexible sigmoidoscopy reduces incidence of late-stage CRC, mortality
Many lung and esophageal cancer survivors have positron emission tomography imaging scans as part of ongoing monitoring

PET Scans May Be Overused in Monitoring of Cancer Survivors

Study finds using costly test as first option for follow-up may not improve survival
Quality of life after a ductal carcinoma in situ diagnosis is generally comparable to that of similarly aged women without the diagnosis

Quality of Life After DCIS Diagnosis Doesn’t Decline

At two years after diagnosis, physical, mental measures same as non-cancer patients
New mutations have been identified with next-generation sequencing in refractory anemia with ring sideroblasts and thrombocytosis

New Mutations Help Predict Survival in RARS-T

Mutations help classify risk in refractory anemia with ring sideroblasts and thrombocytosis
Higher body weight and taller stature during adolescence are associated with increased risk of non-Hodgkin's lymphoma

Teen Weight, Height Linked to Non-Hodgkin’s Lymphoma

Weight and height predict NHL subtypes in cohort of >2,000,000 16- to 19-year-olds