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Hematology and Oncology

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Octamer-binding transcription factor 4 is a predictive marker for patients with digestive system cancers

Oct4 Found to Be a Prognostic Marker for Digestive Cancers

Elevated Oct4 levels tied to poor overall, disease-free, and recurrence-free survival
Patients with muscle invasive bladder cancer who undergo neoadjuvant chemotherapy before and after radical cystectomy frequently experience thromboembolic events

Thromboembolic Events Common With Chemo for Bladder Cancer

Findings in patients with muscle invasive bladder cancer who undergo neoadjuvant chemotherapy
Discussing the risk of long-term opioid use disorder with patients is associated with reduced misuse of opioids

Discussing Opioid Risks With Patients Reduces Misuse

Sixty percent lower rate of saving of pills among patients who talked to their doctor about risks
Circulating exosomes released under intermittent hypoxia conditions

Intermittent Hypoxia Promotes Lung Tumor Cell Aggressiveness

IH-induced exosomes from mice significantly promote TC1 malignant properties
Clinicians should not screen for thyroid cancer in patients who have no symptoms of the disease

USPSTF Continues to Recommend Against Thyroid Cancer Screening

Widespread routine thyroid cancer screening can lead to overdiagnosis, overtreatment
Men treated with implantable testosterone pellets have a statistically significant increase in mean hematocrit

Small Increase in Hematocrit With Implantable Testosterone

Statistically significant 2.2 percent increase in mean hematocrit unlikely to be clinically relevant
An updated index incorporating gene and molecular alterations can predict survival in non-small-cell lung cancer with brain metastases

Updated Index Predicts Survival in NSCLC With Brain Metastases

Significant prognostic factors include four factors from earlier index, plus EGFR and ALK alterations
Insulin resistance assessed by homeostasis model assessment index correlates with the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection

HOMA2-IR Tied to Hepatocellular Carcinoma Risk in Hepatitis B

HOMA2-IR independently linked to HCC in patients without overt metabolic abnormalities
Testing for human papillomavirus 16/18 has poor sensitivity for triaging women with minor abnormal cytology

Poor Sensitivity for HPV 16/18 in Minor Abnormal Cytology

Review: pooled sensitivity of HPV 16/18 genotyping for CIN3+ about 70 percent for ASC-US or LSIL
Palbociclib can help slow the progression of advanced breast cancer

Palbociclib Efficacious in Metastatic Breast Cancer

Palbociclib-letrozole combination slows disease progression