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There is a positive association between long-term night shift work and the risk of several common cancers for women

Long-Term Night Shift Work Linked to Cancer Risk in Women

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Dose-response pattern seen, with increased risk of breast cancer for every five years of night shift work
The contributions of screening and treatment to decreases in breast cancer mortality vary by molecular subtype

Screening, Therapy Effect Varies by Breast CA Molecular Subtype

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Reductions in breast cancer mortality linked to screening and treatment, but associations vary
TP53 pathogenic variants are overrepresented in children with acute lymphoblastic leukemia and are associated with worse outcomes

TP53 Variants Linked to Childhood ALL, Poor Outcomes

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Carrying germline variants linked to decreased event-free, overall survival; higher risk of second cancers
There is an increased risk of developing cardiovascular disease among patients with idiopathic thrombocytopenic purpura

Idiopathic Thrombocytopenic Purpura Tied to Higher CVD Risk

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Risk further increased among patients with ITP who undergo splenectomy
Hospitals that volunteered to be under financial incentives for more than a decade as part of the Premier Hospital Quality Incentive Demonstration do not have better process scores or lower mortality than hospitals where these incentives were implemented later under the Hospital Value-Based Purchasing program

For Hospitals, No Benefit for Early Adoption of Financial Incentives

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Hospitals with early adoption do not have better process scores, lower mortality than late adopters
In both men and women in the United States

Cancer Death Rate Continuing to Decline in United States

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Continuous drop in combined cancer death rate from 1991 to 2015, resulting in 2,378,600 fewer deaths
Fluorouracil application can reduce the risk of surgery for squamous cell carcinoma for one year among patients with a history of keratinocyte carcinomas

Fluorouracil Tied to Reduced Surgery for Squamous Cell CA

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Reduced risk of squamous cell carcinoma, but not basal cell carcinoma, for one year in at-risk veterans
Breast implants are associated with an increased risk of anaplastic large-cell lymphoma in the breast

Breast Implants Slightly Increase Risk of Breast ALCL

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Implants tied to increased risk of anaplastic large-cell lymphoma; overall risk still very small
Although patients with pre-existing autoimmune disease who receive checkpoint inhibitors (CPIs) are at risk for exacerbation of their disease

Immune-Related Adverse Events Up With Checkpoint Inhibitors

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Most patients with cancer, autoimmune disease have improvement in events without discontinuing therapy
Few modern

Few Immuno-Oncology Agents Reach ASCO Efficacy Thresholds

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Durable survival, response rates rarely recognized as significant by current oncology value frameworks