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Hematology and Oncology

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On average

Most Women Willing to Trade Off Benefits, Risks of Breast Screening

Women are willing to accept 1.72 additional unnecessary follow-ups and willing to pay £79.17
For men with metastatic prostate cancer there is no survival advantage for aggressive therapy over conservative androgen deprivation therapy only

No Benefit for Aggressive Therapy in Metastatic Prostate Cancer

However, mortality higher with conservative therapy in locally advanced, non-metastatic prostate cancer
Despite low-level evidence

AAOS: Stem Cell Tx for Knee OA Costs About $5,000 Per Injection

High cost, rapidly expanding use despite low-level evidence; mean marketed clinical efficacy of 82.2%
A single prostate-specific antigen screening is not associated with a significant difference in prostate cancer mortality after follow-up of 10 years

Single PSA Screening Doesn’t Cut Prostate Cancer Mortality

But screening is associated with increased detection of low-risk prostate cancer
There is little evidence for the clinical validity or utility of circulating tumor DNA assays for solid tumors

Limited Evidence for Clinical Validity, Utility of ctDNA

No evidence for circulating tumor DNA assays in early-stage cancer, residual disease detection
Adolescents smoking electronic-cigarettes only have significantly higher excretion of volatile organic chemical compounds than non-smokers

Excretion of Volatile Organic Compounds Up in Teen E-Smokers

Excretion of metabolites of acrylonitrile, acrolein, propylene oxide, acrylamide, crotonaldehyde up
Implementation of a ban on menthol cigarettes results in an increase in those attempting to quit

Increase in Other Flavored Tobacco Use After Menthol Ban

Increase in percentage of those who attempted to quit at follow-up versus before ban implementation
Survivors of adolescent cancer have higher rates of adverse mental health outcomes than the general population

Risk of Mental Health Visits Up in Childhood Cancer Survivors

Childhood cancer survivors diagnosed by age 4 have elevated risk of severe mental health events
Most patients with uveal melanoma have unmet health information and psychological needs

Unmet Health Needs for Patients With Uveal Melanoma

Most express unmet needs at 1 week, 3 months after diagnosis; drop in unmet needs over time
Calcium supplements

Calcium ± Vit D Supplements Up Risk of Colon Adenomas, Polyps

Late effect findings of sessile serrated adenomas, polyps in those taking calcium with/without vitamin D