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Proton pump inhibitors at higher doses are associated with an increased risk of ischemic stroke

AHA: Proton Pump Inhibitors Tied to Ischemic Stroke Risk

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Researchers concerned about high doses of meds like esomeprazole and omeprazole
Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are associated with increased risk of gastrointestinal adverse events

GI Adverse Events Up With GLP-1 Receptor Agonists

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Risk varies based on dose, background medications, and type of GLP-1 RA
In guidelines published online Nov. 14 in the Journal of Clinical Oncology

Guidelines Developed for HER2 Testing in Gastroesophageal CA

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Tumor specimens should be assessed for HER2 status before initiation of HER2-targeted therapy
Human resource capabilities are positively associated with quality of patient care

HR Capabilities Positively Linked to Quality of Patient Care

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Three human resource practices identified that can improve clinical work behaviors
Some kidney disease might be prevented or treated by managing constipation

Constipation May Be Associated With Poor Kidney Health

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Treating constipation could help prevent kidney damage
Regular aspirin use is associated with a lower risk of colorectal carcinomas with low concentrations of tumor infiltrating lymphocytes

Immune Response May Be Key to Chemopreventive Effect of Aspirin

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Link seen for colorectal tumors with low levels of tumor infiltrating lymphocytes
For patients with cirrhosis with previous spontaneous bacterial peritonitis (SBP)

PPI Use Doesn’t Up Recurrence of Bacterial Peritonitis

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Findings show no increased risk for patients with cirrhosis taking proton pump inhibitors
Colorectal cancer detected after colonoscopy examination is more often located in the proximal colon and more likely to have DNA mismatch repair deficiency

CRC Detected After Colonoscopy Often Located in Proximal Colon

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Tumors more likely to have DNA mismatch repair deficiency, less likely to be metastatic
Patients with multiple areas of dysplastic squamous epithelium have increased risk for metachronous squamous cell carcinomas in the upper aerodigestive tract

Multiple Dysplastic Lesions in Esophagus Up Risk of SCC

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Increased risk of multiple squamous cell carcinomas in esophagus and head and neck
There is a probable interaction between paritaprevir/ritonavir/ombitasvir+dasabuvir plus ribavirin with warfarin

Probable Interaction ID’d for PrOD, Ribavirin With Warfarin

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Case report shows probable interaction for ribavirin with paritaprevir/ritonavir/ombitasvir+dasabuvir