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Long-term proton pump inhibitor use is associated with increased risk of fundic gland polyps

Review Links PPI Use With Risk of Fundic Gland Polyps

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Proton pump inhibitor therapy may also be associated with increased risk of gastric cancer
Privately insured Americans spent nearly 5 percent more on health care last year than in 2014; this increase was significantly more than that seen in previous years and reflects higher costs for prescription drugs

Rising Rx, ER Prices Pushing U.S. Health Care Spending Up

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Prescription drugs are the fastest growing expense, report shows
Octamer-binding transcription factor 4 is a predictive marker for patients with digestive system cancers

Oct4 Found to Be a Prognostic Marker for Digestive Cancers

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Elevated Oct4 levels tied to poor overall, disease-free, and recurrence-free survival
Insulin resistance assessed by homeostasis model assessment index correlates with the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection

HOMA2-IR Tied to Hepatocellular Carcinoma Risk in Hepatitis B

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HOMA2-IR independently linked to HCC in patients without overt metabolic abnormalities
Metformin seems to alter gut microbiota composition

Metformin Alters Gut Microbiota Composition in Diabetes

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Higher relative abundance of A. muciniphila, SCFA-producing microbiota for metformin-treated diabetes
Patients with moderate-to-severe Crohn's disease who haven't responded to other treatments may benefit from the drug ustekinumab (Stelara)

Ustekinumab Shows Promise in Crohn’s Disease

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Medication potentially helpful in those for whom other treatments haven't worked
A new type of acoustic sensor that resembles a small Band-Aid on the skin can monitor heartbeat and other health measures

Smart Skin Patch Can Monitor Body Function Acoustically

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Device offers capability for continuous listening to and recording sounds, low-frequency vibrations
Proton pump inhibitors at higher doses are associated with an increased risk of ischemic stroke

AHA: Proton Pump Inhibitors Tied to Ischemic Stroke Risk

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Researchers concerned about high doses of meds like esomeprazole and omeprazole
Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are associated with increased risk of gastrointestinal adverse events

GI Adverse Events Up With GLP-1 Receptor Agonists

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Risk varies based on dose, background medications, and type of GLP-1 RA
In guidelines published online Nov. 14 in the Journal of Clinical Oncology

Guidelines Developed for HER2 Testing in Gastroesophageal CA

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Tumor specimens should be assessed for HER2 status before initiation of HER2-targeted therapy