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BRCA1 Mutation May Reduce Women’s Fertility

The BRCA1 mutation may speed the aging of a woman’s ovaries

WEDNESDAY, April 20, 2016 (HealthDay News) — The BRCA1 gene mutation may also be tied to potential fertility issues, according to a report published online April 20 in Human Reproduction.

Kelly-Anne Phillips, M.D., a consultant medical oncologist at the Peter MacCallum Cancer Center in East Melbourne, Australia, and colleagues measured anti-Müllerian hormone (AMH) levels from 693 women who had no history of cancer and were enrolled in a breast cancer study based in New Zealand and Australia between 1997 and 2012. The women were between the ages of 25 and 45. In all, 172 women were carriers and 216 were non-carriers from families with BRCA1 mutations. In addition, 147 were carriers and 158 were non-carriers from families with BRCA2 mutations.

The researchers discovered that the BRCA1 gene mutation was tied to a 25 percent lower level of AMH. This effect was not seen, however, in women with the BRCA2 mutation.

Phillips told HealthDay it’s possible that the BRCA1 mutation may affect DNA repair. Inefficient DNA repair has been shown to contribute to the aging of a woman’s eggs, she explained. “Although BRCA1 is thought of as a cancer gene, there are other implications that are not cancer-related,” Phillips said. “A woman who is a BRCA1 carrier at age 35 has ovaries that look more like the ovaries of a 37-year-old, non-BRCA1 carrier.”

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