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Neuronal heparan sulfates modulate brain amyloid-β clearance and aggregation in a mouse model of Alzheimer's disease

Neuronal Heparan Sulfates Play Role in Amyloid Pathology

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Removal of neuronal HS linked to reduction in Aβ oligomerization and deposition of amyloid plaques
Baricitinib

Baricitinib Superior to Placebo in Refractory Rheumatoid Arthritis

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Findings based on patients with previous inadequate response to biologics
Oral estradiol therapy is associated with less progression of subclinical atherosclerosis in postmenopausal women when therapy is initiated early in menopause

Early Menopause Estradiol Tx Cuts Atherosclerosis Advance

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Positive effect seen only on carotid-artery intima-media thickness
Use of nonoperative management of rectal cancer is increasing

Non-Surgical Management of Rectal Cancer Increasing

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But, findings show use more likely in black, uninsured, and Medicaid patients
Omalizumab is effective in patients with moderate-to-severe chronic spontaneous urticaria symptoms and angioedema unresponsive to high doses of antihistamine treatment

Omalizumab Effective for Chronic Spontaneous Urticaria

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Treatment improves quality of life, cuts angioedema recurrence
A long-acting formulation of the integrase inhibitor raltegravir can protect humanized bone marrow-liver-thymus mice from high-dose vaginal HIV challenges

Long-Acting Raltegravir Shows Promise in Protection from HIV

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Long-acting formulation protects humanized mice from repeated high-dose vaginal HIV challenges
Defitelio (defibrotide sodium) has been approved by the U.S. Food and Drug Administration to treat a rare

FDA Approves First Tx for Disease Linked to Stem Cell Transplant

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Hepatic veno-occlusive disease is rare, but fatal
The candidate viral entry receptor for Zika virus

Entry Receptor for Zika Virus Identified in Brain, Retina

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AXL highly expressed by human radial glia, brain capillaries, and microglia in developing human cortex
Intracoronary delivery of adenovirus 5 encoding adenylyl cyclase 6 is safe for patients with heart failure and reduced ejection fraction

Gene Transfer Explored As Way to Up LV Function in Heart Failure

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AC6 gene transfer increased left ventricular function through a single administration
Extended-release naltrexone is associated with a lower rate of opioid relapse than usual treatment among criminal justice offenders

Naltrexone ER Injection Cuts Opioid Relapse Rate in Inmates

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Lower rate of relapse compared with usual treatment in trial involving criminal justice offenders