Here are what the editors at HealthDay consider to be the most important developments in Pathology for August 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Biomarker Score May Help Predict Response to Cancer Treatment
WEDNESDAY, Aug. 31, 2016 (HealthDay News) — Fourteen genes have been identified that may help determine whether a cancer treatment could help a patient, according to a study published online Aug. 31 in Nature Communications.
Ebola Virus Lingers in Semen Longer Than Expected
WEDNESDAY, Aug. 31, 2016 (HealthDay News) — Ebola virus stays present in semen longer than previously thought, and is more likely to be found in older men, according to a study published online Aug. 30 in The Lancet Global Health.
Retinoic Acid May Help Prevent, Treat Colorectal Cancer
WEDNESDAY, Aug. 31, 2016 (HealthDay News) — Retinoic acid might have a role in suppressing colorectal cancer (CRC), according to experimental research published online Aug. 30 in Immunity.
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TBC1D4 Mutation Common in North American Inuit
WEDNESDAY, Aug. 31, 2016 (HealthDay News) — More than one-quarter of Canadian and Alaskan Inuit have the TBC1D4 mutation resulting in elevated postprandial glucose, and those with prediabetes and type 2 diabetes have increased risk of remaining undiagnosed, according to a study published online Aug. 25 in Diabetes Care.
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Researchers Investigate Three Drugs That Might Fight Zika
TUESDAY, Aug. 30, 2016 (HealthDay News) — Three already existing drugs may offer pregnant women and their developing fetuses protection against the damaging effects of Zika virus, according to a new multicenter study published online Aug. 29 in Nature Medicine.
Acneiform Eruptions Observed After Vemurafenib Treatment
MONDAY, Aug. 29, 2016 (HealthDay News) — Acneiform eruptions due to the BRAF kinase inhibitor (BRAFi) vemurafenib in a patient with multiple metastatic melanoma lesions are described in a case report published online Aug. 11 in the Journal of Dermatology.
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CDC: Zika Transmitted by Sex Partner With No Symptoms
FRIDAY, Aug. 26, 2016 (HealthDay News) — U.S. health officials report that the Zika virus can be spread sexually even when a partner shows no signs of infection. The research was published in the Aug. 26 early-release issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.
Bronchiolitis Plus Gene Variant Raises Asthma Risk in Children
FRIDAY, Aug. 26, 2016 (HealthDay News) — A common genetic variation significantly increases the odds of asthma in children who’ve had a severe respiratory illness at a young age, according to research published online Aug. 24 in PLOS ONE.
CDC: Synthetic Fentanyl a Major Factor in Opioid Overdose Deaths
FRIDAY, Aug. 26, 2016 (HealthDay News) — Deaths from overdoses of illicitly manufactured fentanyl have increased significantly in recent years, according to research published in the Aug. 26 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.
Major Depressive Disorder Ups Acute MI Risk in HIV-Infected
FRIDAY, Aug. 26, 2016 (HealthDay News) — For HIV-infected adults, major depressive disorder (MDD) is associated with an increased risk of acute myocardial infarction (AMI), according to a study published online Aug. 24 in JAMA Cardiology.
IARC: Absence of Excess Body Fat Lowers Risk of Many Cancers
THURSDAY, Aug. 25, 2016 (HealthDay News) — Excess weight is linked to risk of developing at least eight types of cancer, according to a report published in the Aug. 25 issue of the New England Journal of Medicine.
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Diabetes, Insulin Resistance Adversely Affect LV Function
THURSDAY, Aug. 25, 2016 (HealthDay News) — Early exposure to diabetes mellitus (DM) or higher insulin resistance (IR) has an adverse effect on left ventricular (LV) remodeling and function, according to research published online Aug. 17 in JACC: Cardiovascular Imaging.
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Intussusception Hospitalization Rate Up at Age 8 to 11 Weeks
THURSDAY, Aug. 25, 2016 (HealthDay News) — Children aged 8 to 11 weeks have an increased rate of intussusception hospitalization after introduction of rotavirus vaccine, according to a study published online Aug. 24 in Pediatrics.
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Higher Incidence of Edema With Bacteriuria in C1-INH-HAE
THURSDAY, Aug. 25, 2016 (HealthDay News) — For patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE), those with bacteriuria have a higher number of edematous attacks, according to a study published online Aug. 22 in Allergy.
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Circulating Biomarkers May Be Indicative of Stroke Risk
THURSDAY, Aug. 25, 2016 (HealthDay News) — In the future, a simple blood test might gauge a patient’s odds of incident ischemic stroke (IIS), according to a study published online Aug. 24 in Neurology.
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Cancer Replaces CVD As Leading Cause of Death in 22 States
THURSDAY, Aug. 25, 2016 (HealthDay News) — The gap between heart disease and the second-leading cause of death, cancer, has been narrowing since 1968, according to an August data brief published by the U.S. Centers for Disease Control and Prevention’s National Center for Health Statistics (NCHS).
Obese Women Have Greater Adipose Stores of Vitamin D
THURSDAY, Aug. 25, 2016 (HealthDay News) — Obese women have significantly greater total vitamin D stores than normal-weight women, although the pattern of distribution of the stores is similar, according to a study published online Aug. 20 in the Journal of Bone and Mineral Research.
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CDC Urges Prevention, Early Recognition of Sepsis
WEDNESDAY, Aug. 24, 2016 (HealthDay News) — Many cases of life-threatening sepsis could be recognized and treated long before they cause severe illness or death, according to an Aug. 23 Vital Signs report from the U.S. Centers for Disease Control and Prevention.
ACOG Addresses Thrombocytopenia in Pregnancy
WEDNESDAY, Aug. 24, 2016 (HealthDay News) — Thrombocytopenia is common in pregnancy and can have causes that are serious medical disorders, with potential for maternal and fetal morbidity, according to a Practice Bulletin published in the September issue of Obstetrics & Gynecology.
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Genetics May Help Identify Infection in Febrile Infants
WEDNESDAY, Aug. 24, 2016 (HealthDay News) — A quick genetic test might one day help doctors determine within hours whether an infant’s fever is from a virus or a serious bacterial infection, according to two studies published in the Aug. 23/30 issue of the Journal of the American Medical Association.
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Imaging Shows Zika-Linked Congenital Brain Abnormalities
TUESDAY, Aug. 23, 2016 (HealthDay News) — Imaging is revealing a wide variety of brain defects, eye defects, hearing issues, and stunted growth in newborns whose mothers were infected with the Zika virus, according to the special report published online Aug. 23 in Radiology.
Donor Fecal Microbiota Transplant Effective for C. difficile Infection
TUESDAY, Aug. 23, 2016 (HealthDay News) — For patients with recurrent Clostridium difficile infection (CDI), donor fecal microbiota transplantation (FMT) is safe and more efficacious than autologous FMT, according to a study published online Aug. 23 in the Annals of Internal Medicine.
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Success, Safety Up for ART With Elective Single Embryo Transfer
TUESDAY, Aug. 23, 2016 (HealthDay News) — An updated Committee Opinion urges providers of assisted reproductive technology (ART) to do everything possible to reduce the likelihood of a multifetal pregnancy. The report is published in the September issue of Obstetrics & Gynecology.
In Utero Exposure to Banned PCB Chemicals Tied to Autism Risk
TUESDAY, Aug. 23, 2016 (HealthDay News) — Children exposed to high levels of polychlorinated biphenyls (PCBs) in utero may have an increased risk of developing autism, according to research published online Aug. 23 in Environmental Health Perspectives.
Stem Cells May Help Reverse Ischemic Stroke Damage
TUESDAY, Aug. 23, 2016 (HealthDay News) — An experimental treatment combining transplanted neural stem cells with the protein 3K3A-APC shows it may be possible to reverse brain damage after a stroke, according to a study published online Aug. 22 in Nature Medicine.
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Repeated Antibiotic Use in Children May Contribute to T1DM
TUESDAY, Aug. 23, 2016 (HealthDay News) — Repeated treatments with antibiotics have been linked to the development of type 1 diabetes in mice, according to a study published online Aug. 22 in Nature Microbiology.
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CDC Updates Guidance on Infants With Congenital Zika
MONDAY, Aug. 22, 2016 (HealthDay News) — The U.S. Centers for Disease Control and Prevention has released updated interim clinical guidance for health care providers caring for infants born to mothers with possible Zika infection during pregnancy.
Slight Decline in U.S. Prevalence of Latent TB From 2000 to 2011
MONDAY, Aug. 22, 2016 (HealthDay News) — From 2000 to 2011 there was a slight decline in the prevalence of latent tuberculosis infection (LTBI) in the United States, according to a study published in the Aug. 15 issue of the American Journal of Respiratory and Critical Care Medicine.
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Albuminuria Linked to Higher Nighttime SBP in Hypertension
MONDAY, Aug. 22, 2016 (HealthDay News) — For patients with hypertension, albuminuria is associated with higher nighttime systolic blood pressure (SBP), according to a study published online Aug. 11 in Diabetes Care.
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Novel Technique Feasible for Clean-Catch Urine in Infants
FRIDAY, Aug. 19, 2016 (HealthDay News) — A new noninvasive bladder stimulation technique can obtain clean-catch urine (CCU) in infants aged younger than 90 days, according to a study published online Aug. 19 in Pediatrics.
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Five Local Zika Cases Now Confirmed in Miami Beach
FRIDAY, Aug. 19, 2016 (HealthDay News) — Florida Gov. Rick Scott confirmed on Friday that local transmission of the Zika virus has occurred in Miami Beach, with a total of five cases reported so far.
Coronary Heart Disease Risk Up in Patients With Gallstones
FRIDAY, Aug. 19, 2016 (HealthDay News) — Patients with history of gallstone disease may have a slightly increased risk of developing coronary heart disease (CHD), according to research published online Aug. 18 in Arteriosclerosis, Thrombosis, and Vascular Biology.
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Diet in Pregnancy Could Affect Odds of ADHD in Offspring
FRIDAY, Aug. 19, 2016 (HealthDay News) — An unhealthy diet during pregnancy could influence a child’s risk of attention-deficit/hyperactivity disorder (ADHD), according to a study published online Aug. 18 in the Journal of Child Psychology and Psychiatry.
USPSTF Ruling Followed by Fall in Early Prostate Cancer Diagnoses
FRIDAY, Aug. 19, 2016 (HealthDay News) — Diagnoses of early prostate cancer continue to decline in the United States, following the U.S. Preventive Services Task Force recommendation against routine screening, according to a research letter published online Aug. 18 in JAMA Oncology.
Research Offers Insight Into Zika Virus Transmission to Placenta
FRIDAY, Aug. 19, 2016 (HealthDay News) — Primary human placental macrophages, known as Hofbauer cells, and placental villous fibroblasts are susceptible to infection by Zika virus, according to research published online Aug. 18 in JCI Insight.
Antimicrobial Tx Duration Often Exceeds Recommendations
FRIDAY, Aug. 19, 2016 (HealthDay News) — Antimicrobials are often prescribed for a longer duration than recommended in guidelines, according to a study published online Aug. 16 in the Journal of Hospital Medicine.
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Monogenic Forms of Diabetes Can Occur in Preterm Infants
THURSDAY, Aug. 18, 2016 (HealthDay News) — Monogenic forms of diabetes can occur in preterm infants, according to a study published online Aug. 18 in Pediatrics.
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F12, STC2 Genes May Help Predict Breast Cancer Survival
THURSDAY, Aug. 18, 2016 (HealthDay News) — The activity of two genes may help predict certain breast cancer patients’ odds of survival and guide their treatment, according to research published online Aug. 17 in Oncotarget.
Legal Issues Impact Delivery of Telehealth
THURSDAY, Aug. 18, 2016 (HealthDay News) — Telehealth technologies can allow delivery of high-quality care at a lower cost, especially in underserved areas, but there is currently no uniform legal approach to telehealth, hampering its provision, according to a Health Policy Brief published online Aug. 15 in Health Affairs.
Diabetes Linked to Increased CVD, Cancer, Other Mortality
THURSDAY, Aug. 18, 2016 (HealthDay News) — Diabetes is associated with increased mortality from cardiovascular disease, cancer, and noncardiovascular noncancer causes, according to a study published online Aug. 4 in Diabetes Care.
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Misclassification of Variants As Pathogenic in Black Americans
THURSDAY, Aug. 18, 2016 (HealthDay News) — Variants that have previously been considered causal in hypertrophic cardiomyopathy are often misclassified as pathogenic in patients with African or unspecified ancestry, according to a study published in the Aug. 18 issue of the New England Journal of Medicine.
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Sociodemographic Factors Affect Prostate CA Treatment Initiation
THURSDAY, Aug. 18, 2016 (HealthDay News) — For men with low-risk prostate cancer undergoing active surveillance, sociodemographic factors are associated with initiation of active treatment, according to a study published in the September issue of The Journal of Urology.
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Residents Often Order Perceived Unnecessary Lab Tests
WEDNESDAY, Aug. 17, 2016 (HealthDay News) — Residents frequently order perceived unnecessary inpatient laboratory tests, according to a study published online Aug. 13 in the Journal of Hospital Medicine.
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Season, Region of Birth May Influence Celiac Disease Risk
WEDNESDAY, Aug. 17, 2016 (HealthDay News) — Where and when children are born may affect their risk for celiac disease, according to a study published online Aug. 15 in the Archives of Disease in Childhood.
Proposed Change Could Improve Liver Transplant Access
TUESDAY, Aug. 16, 2016 (HealthDay News) — A new proposal would mean where Americans live will no longer affect how long they have to wait for a liver transplant.
U.S. Female Doctors Reimbursed Significantly Less Than Males
TUESDAY, Aug. 16, 2016 (HealthDay News) — Female doctors in the United States make much less than their male colleagues, according to a study published online Aug. 15 in the Postgraduate Medical Journal.
Expanded Carrier Screening May Up Detection of Genetic Disorders
TUESDAY, Aug. 16, 2016 (HealthDay News) — Compared with current recommendations from professional societies, expanded carrier screening may increase the detection of carrier status for potentially serious genetic conditions, according to a study published in the Aug. 16 issue of the Journal of the American Medical Association.
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Prevalence of Gestational Diabetes Up in U.S. Since 1979
TUESDAY, Aug. 16, 2016 (HealthDay News) — The prevalence of gestational diabetes mellitus (GDM) has increased considerably over time in the United States, according to a study published online Aug. 11 in BJOG: An International Journal of Obstetrics & Gynaecology.
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Antimicrobial Resistance to Carbapenems Increasing
TUESDAY, Aug. 16, 2016 (HealthDay News) — Antimicrobial resistance to carbapenems has increased, and consumption of antibiotics, especially carbapenems, is associated with antimicrobial resistance of Pseudomonas aeruginosa, according to a study published online Aug. 11 in the Journal of Clinical Pharmacy and Therapeutics.
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Pre-Op Urine Culture Doesn’t Predict Stone Culture
MONDAY, Aug. 15, 2016 (HealthDay News) — For patients undergoing percutaneous stone removal, preoperative urine culture does not predict intraoperative stone culture results, according to a study published in the September issue of The Journal of Urology.
Cancer Now Leading Cause of Death in Some European Nations
MONDAY, Aug. 15, 2016 (HealthDay News) — Cancer has overtaken cardiovascular disease (CVD) as the leading cause of death in 12 European countries, according to a study published online Aug. 14 in the European Heart Journal.
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OCT1, SERT Genes Play Role in Metformin Intolerance
MONDAY, Aug. 15, 2016 (HealthDay News) — The interaction between the organic cation transporter 1 (OCT1) and the serotonin reuptake transporter (SERT) seems to play a role in metformin intolerance, according to a study published online Aug. 4 in Diabetes Care.
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Review Links Anxiety Disorders to Risk of Cardiovascular Events
FRIDAY, Aug. 12, 2016 (HealthDay News) — Anxiety disorders are associated with a range of cardiovascular events, according to a meta-analysis published in the Aug. 15 issue of The American Journal of Cardiology.
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RSV Found in Aerosol Particles Surrounding Infants With RSV
FRIDAY, Aug. 12, 2016 (HealthDay News) — Infants with respiratory syncytial virus (RSV)-positive bronchiolitis produce large numbers of aerosol particles containing RSV that remain infectious for a significant length of time, according to a study published in the Aug. 1 issue of the American Journal of Respiratory and Critical Care Medicine.
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Onsite Tests Have High Specificity for Bacteriuria
FRIDAY, Aug. 12, 2016 (HealthDay News) — Onsite tests have high specificity for detecting asymptomatic bacteriuria among pregnant women, but sensitivity is lower, according to a review published in the September issue of Obstetrics & Gynecology.
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Venetoclax Monotherapy Active in AML With Adverse Features
FRIDAY, Aug. 12, 2016 (HealthDay News) — In patients with high-risk relapsed/refractory acute myelogenous leukemia (AML) or untreated AML unfit for intensive chemotherapy, the highly selective, oral small-molecule B-cell leukemia/lymphoma-2 (BCL2) inhibitor venetoclax is active, according to a study published online Aug. 12 in Cancer Discovery.
Considerable Health Care System Burden for Undiagnosed COPD
FRIDAY, Aug. 12, 2016 (HealthDay News) — The overall health system burden of exacerbations in patients with undiagnosed chronic obstructive pulmonary disease (COPD) is considerable, according to a study published in the Aug. 1 issue of the American Journal of Respiratory and Critical Care Medicine.
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Rosacea Tied to Higher Risk of GI Diseases
FRIDAY, Aug. 12, 2016 (HealthDay News) — Rosacea is associated with increased risk of some gastrointestinal diseases, according to a study published online Aug. 8 in the British Journal of Dermatology.
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Zika Virus Proteins NS4A, NS4B Associated With Microcephaly
FRIDAY, Aug. 12, 2016 (HealthDay News) — The Zika virus contains 10 proteins, but only two — NS4A and NS4B — are linked to microcephaly, according to a study published online Aug. 11 in Cell Stem Cell.
M. pneumoniae Infection Linked to Guillain-Barré Syndrome
FRIDAY, Aug. 12, 2016 (HealthDay News) — Mycoplasma pneumoniae infection is associated with Guillain-Barré syndrome (GBS), according to a study published online Aug. 4 in the Annals of Neurology.
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ESR1 Mutations Tied to Worse Survival in Metastatic Breast CA
THURSDAY, Aug. 11, 2016 (HealthDay News) — For patients with estrogen receptor (ER)-positive metastatic breast cancer (MBC), estrogen receptor α (ESR1) mutations are prevalent and associated with shorter overall survival, according to a study published online Aug. 11 in JAMA Oncology.
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Tx Response No Different for Migalastat, Placebo in Fabry’s
THURSDAY, Aug. 11, 2016 (HealthDay News) — For patients with Fabry’s disease, the percentage of patients with response at six months does not differ for those treated with the oral pharmacologic chaperone migalastat or with placebo, according to a study published in the Aug. 11 issue of the New England Journal of Medicine.
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Frozen Embryos May Outperform Fresh for Women With PCOS
THURSDAY, Aug. 11, 2016 (HealthDay News) — For women with polycystic ovary syndrome seeking infertility treatment, the use of frozen embryos rather than fresh appears to improve the chances for a successful pregnancy, according to a study published in the Aug. 11 issue of the New England Journal of Medicine.
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Florida Reports Four More Cases of Local Zika Infection in Miami
WEDNESDAY, Aug. 10, 2016 (HealthDay News) — Four more cases of Zika infection that were likely spread through mosquito bites have been reported in the Miami area, bringing the total count of cases to 21, Florida Gov. Rick Scott said Tuesday.
Suicide Rate Increased in Patients With Serious Infections
WEDNESDAY, Aug. 10, 2016 (HealthDay News) — Patients hospitalized for serious infections may face an increased risk of suicide, according to research published online Aug. 10 in JAMA Psychiatry.
Risk of Post-Op Opioid Abuse Deemed Low for Elderly Patients
WEDNESDAY, Aug. 10, 2016 (HealthDay News) — Opioid abuse arises in only a very small fraction — less than half of 1 percent — of cases involving surgical patients aged 65 or older, according to a research letter published online Aug. 10 in JAMA Surgery.
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Many U.S. Hospitals Offer Language Services
WEDNESDAY, Aug. 10, 2016 (HealthDay News) — Overall, 68.8 percent of hospitals offer language services, with the proportion increasing with level of need, according to research published in the August issue of Health Affairs.
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Zika May Be Responsible for Arthrogryposis in Newborns
WEDNESDAY, Aug. 10, 2016 (HealthDay News) — The Zika virus may be the cause of joint deformities in the arms and legs of newborns (arthrogryposis), according to a report published online Aug. 9 in The BMJ.
Counterfeit Alprazolam Cut With Fentanyl Can Be Fatal
WEDNESDAY, Aug. 10, 2016 (HealthDay News) — At least one San Francisco-area individual died and eight more were treated in the emergency department in late 2015 after taking counterfeit alprazolam (Xanax) tablets that had been cut with fentanyl, according to a case report published online Aug. 8 in JAMA Internal Medicine.
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Dermatopathology More Common in Crohn’s Than Ulcerative Colitis
WEDNESDAY, Aug. 10, 2016 (HealthDay News) — Cutaneous manifestations of inflammatory bowel disease (IBD) should be considered when reviewing unexplained skin lesions, particularly in patients with Crohn’s disease (CD), according to research published online Aug. 6 in the Journal of Cutaneous Pathology.
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No Recent Change in Prevalence of Diabetic Kidney Disease
WEDNESDAY, Aug. 10, 2016 (HealthDay News) — From 1988 to 2014 there was no change in the overall prevalence of diabetic kidney disease, according to a study published in the Aug. 9 issue of the Journal of the American Medical Association.
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Modest Changes in Practice for High-Sensitivity TnT Reporting
WEDNESDAY, Aug. 10, 2016 (HealthDay News) — For patients presenting to the emergency department with chest pain, high-sensitivity troponin T (hs-TnT) reporting is associated with modest changes in practice, according to a study published online Aug. 9 in Circulation: Cardiovascular Quality and Outcomes.
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Western Diet May Contribute to Dense Breasts
TUESDAY, Aug. 9, 2016 (HealthDay News) — Overweight and obese women who eat a Western diet may develop more dense breast tissue, possibly increasing their risk for breast cancer, according to research published in the September issue of Obstetrics and Gynecology.
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USPSTF: Evidence Lacking for Lipid Screening in Children, Teens
TUESDAY, Aug. 9, 2016 (HealthDay News) — The U.S. Preventive Services Task Force (USPSTF) has concluded that the evidence is currently insufficient to weigh the balance of benefits and harms of screening for lipid disorders in children and adolescents (aged 20 years or younger). These findings form the basis of a final recommendation statement published in the Aug. 9 issue of the Journal of the American Medical Association.
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Many Americans Exposed to Toxic Chemicals in Drinking Water
TUESDAY, Aug. 9, 2016 (HealthDay News) — The levels of polyfluoroalkyl and perfluoroalkyl substances (PFASs) in drinking water exceed government-recommended safety levels for at least six million people in the United States, according to a report published online Aug. 9 in Environmental Science & Technology Letters.
Soy Isoflavones Beneficial in Polycystic Ovary Syndrome
TUESDAY, Aug. 9, 2016 (HealthDay News) — For women with polycystic ovary syndrome (PCOS), soy isoflavones improve metabolic status, according to a study published online Aug. 4 in the Journal of Clinical Endocrinology & Metabolism.
hs-CRP Predicts Depression Treatment Response in T1DM
TUESDAY, Aug. 9, 2016 (HealthDay News) — Higher baseline high-sensitivity C-reactive protein (hs-CRP) is associated with less treatment-linked improvement in depression in patients with type 1 diabetes, according to a study published online Aug. 3 in Diabetes Care.
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Distress Over False-Positive Cystic Fibrosis Screen Not Lasting
MONDAY, Aug. 8, 2016 (HealthDay News) — Mothers of infants with false-positive (FP) newborn bloodspot screening (NBS) results for cystic fibrosis (CF) report immediate distress, although these concerns are not reflected in psychosocial response measures, according to a study published online Aug. 2 in Pediatrics.
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Braided Suture Linked to Adverse Outcomes in Cervical Cerclage
FRIDAY, Aug. 5, 2016 (HealthDay News) — For women with short cervical length undergoing cervical cerclage, braided suture induces a persistent shift toward vaginal microbiome dysbiosis, and is associated with increased intrauterine death and preterm birth compared with monofilament suture, according to a study published online Aug. 3 in Science Translational Medicine.
Animal Studies Show Path for Zika Virus Vaccine in Humans
FRIDAY, Aug. 5, 2016 (HealthDay News) — Three vaccine platforms have demonstrated protective efficacy against Zika virus (ZIKV) challenge in rhesus monkeys, according to research published online Aug. 4 in Science.
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Lipid Fractions May Be Linked to Risk of CAD, Diabetes
FRIDAY, Aug. 5, 2016 (HealthDay News) — Routinely measured lipid fractions may be associated with the risk of coronary artery disease (CAD) and diabetes, according to a study published online Aug. 3 in JAMA Cardiology.
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Prolonged Detection of Zika RNA Reported in Pregnant Women
THURSDAY, Aug. 4, 2016 (HealthDay News) — Prolonged detection of Zika virus RNA has been documented in five pregnant women, according to research published online July 29 in Obstetrics & Gynecology.
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Metabolic Factors May Contribute to Tx Resistance in Renal Cancer
THURSDAY, Aug. 4, 2016 (HealthDay News) — Tumor cell-intrinsic metabolic factors may contribute to anti-programmed death 1 (PD-1)/PD-L1 treatment resistance in renal cell carcinoma (RCC), according to a study published online Aug. 4 in Cancer Immunology Research.
Amish Farm Environment May Protect Children From Asthma
THURSDAY, Aug. 4, 2016 (HealthDay News) — The Amish environment seems to provide protection against asthma and allergic sensitization, according to a study published in the Aug. 3 issue of the New England Journal of Medicine.
C-Peptide Responses Reliable Surrogates of Insulin Secretion
THURSDAY, Aug. 4, 2016 (HealthDay News) — C-peptide responses to mixed-meal tolerance tests are reliable surrogates of insulin secretion, according to a study published online July 15 in Diabetes Care.
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M-CSF Plays Role in Host Defense in Bacterial Pneumonia
THURSDAY, Aug. 4, 2016 (HealthDay News) — The cytokine M-CSF promotes survival of lung and liver mononuclear phagocytes to mediate host defense during bacterial pneumonia, according to an experimental study published in the June 15 issue of The Journal of Immunology.
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Proinflammatory Response in Women With Vaginal Mesh
WEDNESDAY, Aug. 3, 2016 (HealthDay News) — Women with vaginal mesh with complications have a significantly increased proinflammatory response, according to a study published in the August issue of the American Journal of Obstetrics & Gynecology.
Study IDs Two Novel Loci Linked to Insulin Sensitivity
WEDNESDAY, Aug. 3, 2016 (HealthDay News) — Two novel loci have been identified that are associated with insulin sensitivity, according to a study published online July 14 in Diabetes.
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Sickle Cell Trait Doesn’t Up Mortality Risk in U.S. Soldiers
WEDNESDAY, Aug. 3, 2016 (HealthDay News) — Sickle cell trait is not associated with a higher risk of death than absence of the trait, but it is associated with a significantly increased risk of exertional rhabdomyolysis, according to a study published in the Aug. 4 issue of the New England Journal of Medicine.
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Third Dose of MMR Vaccine Can Help Control Mumps Outbreaks
WEDNESDAY, Aug. 3, 2016 (HealthDay News) — A third dose of measles-mumps-rubella (MMR) vaccine is recommended in cases of mumps outbreak in which transmission is sustained despite high two-dose MMR coverage, according to research published in the July 29 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.
BRAF Inhibitors May Accelerate Wound Healing
WEDNESDAY, Aug. 3, 2016 (HealthDay News) — Topical application of BRAF inhibitors may accelerate healing of skin wounds, according to a study published online Aug. 1 in Nature Communications.
Targeted Therapies Beneficial in KRAS-Mutated NSCLC
WEDNESDAY, Aug. 3, 2016 (HealthDay News) — Targeted therapies that do not contain erlotinib can be beneficial for patients with KRAS-mutated (KRAS mut+) advanced non-small-cell lung cancer (NSCLC), according to a study published online Aug. 1 in the Journal of Clinical Oncology.
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Mortality Up With Impaired Glucose Tolerance
WEDNESDAY, Aug. 3, 2016 (HealthDay News) — Patients with impaired glucose tolerance (IGT) face an increased risk of mortality, with much of the increased risk of mortality associated with progression to type 2 diabetes, according to a study published online July 13 in Diabetes Care.
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USPSTF Recommends Against Screening for Genital Herpes
TUESDAY, Aug. 2, 2016 (HealthDay News) — The U.S. Preventive Services Task Force (USPSTF) recommends against routine serologic screening for genital herpes simplex virus (HSV) infection in adolescents and adults who are asymptomatic, including pregnant women. These findings form the basis of a draft recommendation statement published online Aug. 2 by the USPSTF.
Evidence Review
Draft Recommendation Statement
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High Doses of Omega-3s May Help Healing After Acute MI
TUESDAY, Aug. 2, 2016 (HealthDay News) — Acute myocardial infarction (AMI) patients who take high doses of omega-3 fatty acids for six months show improved heart function and less scarring, according to a study published in the Aug. 2 issue of Circulation.
Twin Study Questions Link Between Obesity, Heart Risk
TUESDAY, Aug. 2, 2016 (HealthDay News) — A study of identical twins, published online Aug. 1 in JAMA Internal Medicine, suggests that obesity may not increase the risk of myocardial infarction (MI) or premature death.
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Urinary Biomarkers Can Predict Response in Lupus Nephritis
TUESDAY, Aug. 2, 2016 (HealthDay News) — Low abundance biomarker panels can predict lupus nephritis outcomes, according to research published online July 27 in Arthritis & Rheumatology.
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Predictors ID’d for Switching to Active Tx in Prostate Cancer
TUESDAY, Aug. 2, 2016 (HealthDay News) — For men with low-risk prostate cancer, factors such as ethnicity influence patient decision to pursue active treatment during active surveillance, according to a study published online in The Journal of Urology.
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Locally-Transmitted Zika Infection Count in Miami Up to 14
MONDAY, Aug. 1, 2016 (HealthDay News) — The number of local transmissions of the Zika virus in South Florida has apparently increased to 14, Gov. Rick Scott said Monday.
15 Genomic Regions Associated With Depression Identified
MONDAY, Aug. 1, 2016 (HealthDay News) — Fifteen regions of human DNA associated with depression have been identified, according to research published online Aug. 1 in Nature Genetics.
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ASBS: Contralateral Prophylactic Mastectomy Discouraged
MONDAY, Aug. 1, 2016 (HealthDay News) — Contralateral prophylactic mastectomy should generally be discouraged in average-risk women, whose chances of developing breast cancer in the healthy breast are only 0.1 to 0.6 percent a year, according to a new American Society of Breast Surgeons position statement published online July 28 in the Annals of Surgical Oncology.
European Countries Implementing Cost-Sharing
MONDAY, Aug. 1, 2016 (HealthDay News) — European health systems are requiring an increase in cost-sharing measures for patients 50 years of age and older, according to research published in the July issue of Health Affairs.
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Hospitalizations for Heart Failure With Preserved EF Common
MONDAY, Aug. 1, 2016 (HealthDay News) — Heart failure with preserved ejection fraction (HFpEF) is common among patients hospitalized with acute heart failure, and patients with HFpEF are older, more often female, and frequently have comorbidities, according to a study published in the June issue of The American Journal of Medicine.
Standardized Tests Can Quantify β-Cell Function
MONDAY, Aug. 1, 2016 (HealthDay News) — Standardized mixed-meal tolerance tests (MMTT) and arginine stimulation tests (AST) provide reproducible measures of β-cell function (BCF) across glucose tolerance states, according to a study published online July 12 in Diabetes Care.
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SFRP4 Linked to Impaired Glucose Tolerance, T2DM
MONDAY, Aug. 1, 2016 (HealthDay News) — Secreted frizzled-related protein 4 (SFRP4) is associated with impaired glucose tolerance (IGT) and type 2 diabetes (T2D), according to a report published online July 6 in Diabetes Care.
[18F]-AV-1451 Shows Staging Potential in Alzheimer’s
MONDAY, Aug. 1, 2016 (HealthDay News) — Use of [18F]-AV-1451 positron emission tomography (PET) can potentially stage Alzheimer’s disease (AD), according to a study published online July 25 in JAMA Neurology.
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