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Patients with desmoplastic melanoma have a high level of objective tumor response to treatment with antibodies to block programmed cell death 1 (PD-1) or PD-1 ligand

High Response of Desmoplastic Melanomas to PD-1 Blockade

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Higher percentage of PD-L1-positive cells in the tumor parenchyma of desmoplastic melanomas
Color-coded compartmentalized "rainbow trays" used for anesthetic drug preparation and storage may improve patient safety

Color-Coded Drug Storage Trays May Cut Medication Errors

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Anesthetists report that 'rainbow trays' help with drug identification and separation
In patients aged 80 and older with advanced non-small-cell lung cancer

Race, Education Level Predict CRT in Very Elderly With NSCLC

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In elderly with stage III lung cancer, black race, lower-educated county tied to not receiving care
Acetaminophen use in pregnancy is associated with language delay among girls

Acetaminophen Use in Pregnancy Linked to Language Delay

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Number of APAP tablets, urinary APAP concentration linked to increased odds of language delay in girls
The use of idalopirdine does not improve cognition versus placebo over 24 weeks of treatment for patients with mild-to-moderate Alzheimer's disease

Idalopirdine May Not Improve Cognition in Mild Alzheimer’s

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Findings from three randomized trials show no improvement in cognition vs. placebo over 24 weeks
A novel oral dosage form enables sustained release of antiretrovirals

Week’s Worth of HIV Meds in a Single-Dose Capsule Feasible

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Oral platform delivers three antiretrovirals for up to seven days after single administration
Higher-intensity end-of-life care may be driven by financial incentives present in fee-for-service Medicare but not in the Veteran Affairs integrated system

Intense End-of-Life Care Found to Be Less Likely for VA Patients

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Authors say results have important implications for the future of VA care, Medicare policy
Rituximab has better efficacy and lower discontinuation rates than other disease-modifying treatment choices for newly diagnosed relapsing-remitting multiple sclerosis

Rituximab Tops Other Disease-Modifying Tx Options in MS

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Better efficacy, lower discontinuation rate in newly diagnosed relapsing-remitting multiple sclerosis
The contributions of screening and treatment to decreases in breast cancer mortality vary by molecular subtype

Screening, Therapy Effect Varies by Breast CA Molecular Subtype

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Reductions in breast cancer mortality linked to screening and treatment, but associations vary
The risk of autism spectrum disorder is reduced in offspring with maternal exposure to folic acid and multivitamin supplementation before and during pregnancy

Maternal Folic Acid, Multivitamin Use May Cut ASD Risk in Offspring

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Autism spectrum disorder risk lower in those whose moms took supplements before, while pregnant