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Tag: Proton Pump Inhibitors

Cumulative PPI Use for More Than 4.4 Years Linked to Increased Risk for Dementia

No significant association seen for lesser durations of proton pump inhibitor use

ASN: PPI Use May Up Risk for AKI After Cardiac Surgery

Adults receiving proton pump inhibitors have increased risk for acute kidney injury requiring dialysis following cardiac surgery

Proton Pump Inhibitor Use Tied to Less Severe Periodontal Disease

Patients with periodontitis who use proton pump inhibitors have fewer teeth with elevated probing depths for the gap between teeth and gums

Add-On PPI Therapy May Improve Glycemic Control in Diabetes

However, treatment with proton pump inhibitors is not associated with risk for incident diabetes in the general population

Child Proton Pump Inhibitor Use May Increase Asthma Risk

Risk increased across all age groups with highest risk for infants and toddlers; risk seen across individual PPIs

Regular use of proton pump inhibitors is associated with an increased risk for type 2 diabetes

Proton Pump Inhibitor Use Linked to Increased T2DM Risk

Type 2 diabetes risk increased with increasing length of PPI use, particularly use for more than two years
For patients with advanced urothelial cancer treated with atezolizumab

PPI Use Is Negative Prognostic Marker in Urothelial Cancer

PPI use linked to significantly worse progression-free, overall survival in advanced urothelial cancer
Adults taking proton pump inhibitors have an increased risk for having a positive COVID-19 test

Risk for COVID-19 Increased for Adults Taking PPIs

Dose-response relationship observed; risk up 3.67-fold for those using PPIs up to twice daily
Recommendations are presented for the management of eosinophilic esophagitis in clinical practice guidelines published in the May issue of Gastroenterology.

Guidelines Issued for Managing Eosinophilic Esophagitis

Topical glucocorticosteroids recommended over no treatment
Stomach acid suppression medications increase the odds of intestinal colonization with multidrug-resistant microorganisms

Suppressing Stomach Acid May Up Intestinal Growth of MDROs

Gastric acid suppression increased odds of intestinal colonization with MDROs by about 75 percent