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Dexmedetomidine prevents excessive γ-aminobutyric acid type A receptor function after anesthesia

Dexmedetomidine Cuts γ-Aminobutyric Acid Receptor Function

Cuts etomidate-induced increase in α5 γ-aminobutyric acid type A receptor cell-surface expression
Ambulatory medication reconciliation is associated with lower risk of a composite primary outcome of combined frequency of emergency department visits and hospitalizations over six months

Diabetes Meds Reconciliation May Reduce Risk of ER Visits

Medication reconciliation linked to lower risk of combined ER visits, hospitalization over six months
The estimated prevalence of using medications with depression as an adverse effect is 37.2 percent

Meds With Depression As Adverse Side Effect Commonly Used

Prevalence of depression higher for adults reporting use of multiple meds with depression as side effect
Topical rapamycin seems effective for tuberous sclerosis complex-related facial angiofibromas

Topical Rapamycin Effective for TSC-Related Facial Angiofibromas

One percent rapamycin seems most effective for tuberous sclerosis complex-linked angiofibromas
Mifepristone pretreatment improves medical management of early pregnancy loss

Mifepristone Pre-Tx Improves Management of Early Miscarriage

Successful management likely for pretreatment with mifepristone followed by misoprostol
A recall of the opioid overdose antidote Naloxone was announced Monday. The U.S. Food and Drug Administration said the recall was triggered by the possibility of "loose particulate matter on the syringe plunger" that could pose a number of health risks

FDA: Opioid Antidote Naloxone Recalled

Two lots of Naloxone recalled due to potential presence of particulate matter in syringe plunger
For patients with programmed death ligand 1 (PD-L1)-expressing locally advanced or metastatic non-small-cell lung cancer

ASCO: Pembrolizumab Superior for Initial Tx of Advanced NSCLC

Improved overall survival versus chemotherapy regardless of the PD-L1 tumor proportion score
For patients with metastatic renal cell carcinoma classified as having intermediate or poor prognostic risk

ASCO: Sunitinib Alone Noninferior in Metastatic Renal Cell Cancer

Sunitinib alone noninferior to nephrectomy plus sunitinib with respect to overall survival
The safety profile of oral propranolol seems to be good for children with infantile hemangioma

Oral Propranolol Seems Safe for Infantile Hemangioma

Good safety profile for children with infantile hemangioma with no prespecified underlying disease
For patients with episodic migraine

Galcanezumab Beats Placebo for Episodic Migraine

Treatment with 120- or 240-mg galcanezumab linked to reduction in migraine days versus placebo