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Patients with rejected or abandoned prescriptions for proprotein convertase subtilisin kexin type 9 inhibitors have a significantly increased risk for cardiovascular events than those with paid prescriptions

CV Event Risk Up With Rejected, Abandoned PCSK9i Prescriptions

Rejection rates higher for PCSK9i prescriptions for women, racial minorities, lower-income groups
A bill to reduce prescription drug costs for millions of Medicare recipients and lower federal and state health costs has been introduced by two U.S. senators.

Senate Bill Would Reduce Drug Costs for Seniors

Bill would limit drug copays for people with Medicare Part D by capping annual out-of-pocket costs
Among patients with moderately to severely active rheumatoid arthritis resistant to previous therapy with biologic agents

Filgotinib Bests Placebo in Tx of Refractory Rheumatoid Arthritis

Clinical response rate higher among patients with active RA resistant to treatment with biologic agents
The number of days supplied of an initial opioid prescription is the strongest risk factor for developing long-term opioid use among previously opioid-free injured workers

Supply of Opioids Predicts Long-Term Use in Injured Workers

Odds of long-term opioid use up with initial Rx for five- to nine-day supply versus supply of less than five days
Patients undergoing preoperative peripheral nerve block placement have a similar change in anxiolytic scores when they receive music medicine versus midazolam

Music Relieves Preop Anxiety Before Peripheral Nerve Block

Similar changes seen in levels of preoperative anxiety for patients receiving music medicine, midazolam
For patients with cystic fibrosis

Key Cystic Fibrosis Pathogens Reduced With Ivacaftor Use

Ivacaftor use linked to reductions in P. aeruginosa rates, prevalence of S. aureus, Aspergillus species
Since initiation of the iPLEDGE program in 2006 to reduce fetal exposure to isotretinoin

Pregnancies in Women Taking Isotretinoin Dropped Since 2006

Pregnancies reduced in women taking isotretinoin since iPLEDGE initiation in 2006, but exposure persists
In patients with membranous nephropathy at high risk for progressive disease

Rituximab Noninferior to Cyclosporine in Membranous Nephropathy

Drug found to be superior in maintaining proteinuria remission for up to 24 months
Patients with autoimmune diseases have an increased risk for being diagnosed with Crohn disease or ulcerative colitis while under treatment with etanercept

Etanercept Tx for Autoimmune Disease May Up Risk for IBD

Findings seen in patients receiving etanercept for other autoimmune diseases
Oliceridine is being proposed as an analgesic option for the relief of moderate to severe acute postoperative pain

Oliceridine Studied for IV Pain Relief After Abdominoplasty

Findings published from phase III trial of patients with moderate-to-severe acute postoperative pain