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After one year of therapy with lumacaftor-ivacaftor in a real-world setting

Lumacaftor-Ivacaftor Aids Cystic Fibrosis in Real-World Setting

Improved lung function, increased BMI, reduced need for IV antibiotics seen after one year of therapy
A class of diabetes drugs

SGLT2 Inhibitors Protect Against Kidney Disease in T2DM

Reduction seen for risk of dialysis, transplantation, or death due to kidney disease
The poly(adenosine diphosphate-ribose) polymerase inhibitor veliparib plus platinum-based chemotherapy for induction therapy

PARP Inhibitor Slows Progression of Advanced Ovarian Cancer

Veliparib added to chemotherapy, continued as maintenance tx prolongs progression-free survival
Hydroxychloroquine blood levels are useful in predicting retinopathy among patients with systemic lupus erythematosus

Hydroxychloroquine Blood Levels Predict Retinopathy Risk in Lupus

Prospective cohort study demonstrates link between HCQ blood levels and retinopathy risk
Over-the-counter medications are commonly used in suicide attempts by self-poisoning among young people

OTC Meds Often Used in Drug-Related Suicide Attempts in Youth

ADHD meds commonly used by those aged 10 to 15 years, while sedative/hypnotics used more by older youth
A triplet combination of therapies (encorafenib

Triplet Tx Ups Survival in BRAF V600E-Mutated Colorectal Cancer

Overall survival longer for encorafenib, cetuximab, and binimetinib combo versus standard therapy
The addition of abemaciclib to fulvestrant provides a statistically significant and clinically meaningful gain in median overall survival

Drug Combo Extends Survival in Advanced Breast Cancer

Benefit seen for addition of CDK4/6 inhibitor after progression of disease on endocrine therapy
Ligelizumab appears to be a safe and effective treatment option for chronic spontaneous urticaria

Ligelizumab Safely, Effectively Treats Hives

Doses of 72 mg or 240 mg tied to complete control of symptoms after 12-week trial
A three-in-one inhaler therapy can improve lung function and reduce asthma attacks in adults with uncontrolled disease

Three-Drug Single Inhaler Treats Uncontrolled Asthma in Adults

Findings seen in two large international clinical trials comparing three-drug inhaler to two-drug inhaler
Initiation of isoniazid preventive therapy during pregnancy is associated with increased risks versus initiation during the postpartum period

Isoniazid Tx to Prevent TB Ups Risks During HIV+ Pregnancy

Deferring treatment until after delivery appears to be safer option