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Automotive assembly plant closures from 1999 to 2016 were associated with increases in opioid overdose mortality

Closures of Automotive Assembly Plants Tied to Opioid OD Deaths

Increases in opioid overdose mortality largest for non-Hispanic white men aged 18 to 34, 35 to 65 years
Older teens may have similar risk factors for prescription opioid overdose as adults

Prescribing Practices Can Mitigate Opioid Overdose Risk for Teens

Lowest amount of opioids, short-acting opioids, avoiding concurrent use of opioids and benzodiazepines cut risk
Buprenorphine treatment may be needed for several years after an opioid overdose to reduce the risk of overdose and other adverse events

Overdose, Relapse After Buprenorphine Discontinuation High

The longer patients continue with buprenorphine treatment, the lower their risk of adverse outcomes
New warnings about the risk for dangerous breathing difficulties when gabapentinoids are used with opioids or by certain patients must now appear on product labels

Gabapentinoids, Opioids Combo Carries Risk for Breathing Problems

Serious breathing problems can occur in patients who use gabapentinoids with opioids or other CNS depressants
The rate of opioid-related suicides as well as unintentional deaths significantly increased from 2000 to 2017

Opioid-Related Suicides Down, Rate of Unintentional Deaths Up

Crises of opioid overdose deaths and suicide do not appear closely linked
Coprescription of benzodiazepines and opioid agonist treatment is associated with an increased risk for drug-related poisoning mortality in opioid-dependent individuals

Benzodiazepines With Opioid Agonist Tx May Up Mortality Risk

Coprescription of z-drugs with OAT also linked to increased risk for drug-related poisoning mortality
The rate of in-hospital births with neonatal abstinence syndrome was 6.7 per 1

Rates of Neonatal Abstinence Syndrome Remain High in U.S.

Highest rates of neonatal abstinence syndrome seen in lowest income quartile, rural areas, Northeast
Among cancer survivors

Factors Predict Adverse Opioid-Related Outcomes in Cancer Survivors

Demographic, cancer, and treatment factors can predict outcomes with high level of discrimination
Overall

6.5 Percent of Adults Report Prescription Opioid Analgesic Use

Percentage using prescription opioid analgesic increased with age; use up for women versus men
Individuals with chronic pain who use daily cannabis have lower odds of using illicit opioids

Daily Cannabis Use Tied to Lower Illicit Opioid Use for Chronic Pain

Findings based on longitudinal study in Canada of people who use drugs and report chronic pain