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Use of oral fluconazole for treatment of vulvovaginal candidiasis in the first trimester of pregnancy is associated with musculoskeletal malformations

Musculoskeletal Malformations Up With Fluconazole in Pregnancy

But no increase seen in conotruncal malformations, oral clefts with use of oral fluconazole in first trimester
Prenatal use of low-dose fluconazole is associated with cleft lip with cleft palate and d-transposition of the great arteries

Fluconazole Use May Raise Risk of Certain Birth Defects

Study shows increased odds of cleft lip with cleft palate, d-transposition of the great arteries
Health care professionals should use caution when prescribing the oral antifungal drug fluconazole (Diflucan) during pregnancy because it may raise the risk of miscarriage

FDA: Fluconazole Linked to Increased Miscarriage Risk

Agency recommends alternatives to fluconazole for mothers-to-be until its review is complete