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Duloxetine Does Not Alleviate Pain in Chronic Osteoarthritis

No differences seen in WOMAC pain at three or 12 months with duloxetine added to usual care, or in subgroup with symptoms of centralized pain

Duloxetine significantly improves osteoarthritis knee pain

Duloxetine Appears Beneficial for Osteoarthritis Knee Pain

Three trials also show improved function with acceptable adverse event rate