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Tag: Cancer: Skin

Pembrolizumab (Keytruda)

AACR: Pembrolizumab Effective Against Merkel-Cell Carcinoma

Intravenous medication blocks programmed death 1 (PD-1) immune inhibitory pathway
More than one-third of advanced melanoma patients were still alive five years after starting therapy with nivolumab (Opdivo)

AACR: Nivolumab Appears to Up Survival in Advanced Melanoma

One-third of study participants lived five years or more after starting treatment
For renal transplant recipients

Oral Nicotinamide Safe for Renal Transplant Recipients

Treatment linked to nonsignificant reductions in new non-melanoma skin cancers
Applying 30 SPF sunscreen to mice before they were exposed to ultraviolet-B radiation delayed the development of melanoma

AACR: SPF 30 Delays Melanoma in Preclinical Model

Study results suggest scientists can use mice to find better ways to prevent melanoma in humans
Wider excision margins in thick cutaneous melanoma cases do not improve locoregional recurrence or melanoma-specific survival

Excision Margins Don’t Impact Melanoma Recurrence, Survival

Although, sentinel lymph node involvement is tied to poor prognosis
There is considerable interpersonal and intrapersonal agreement on the presence of basal cell carcinoma on Mohs slides

Considerable Agreement on Presence of BCC on Mohs Slides

Slides scored as difficult to diagnose independent risk factor for interpersonal discordant diagnosis
Genetics could play a role in the development of melanoma even for skin without extensive sun exposure

MC1R Variants May Up Melanoma Risk, Even Without Sun Exposure

Variant of gene linked to skin pigmentation tied to higher risk
For women aged younger than 50 years

Poor Prognosis for Women With Pregnancy-Associated Melanoma

Among women aged up to 49 years, invasive melanoma less common in those 19 years or younger
In a case report published online Feb. 28 in the Journal of Clinical Pharmacy and Therapeutics

Non-HIV-Related Kaposi Sarcoma in BRAFi-Treated Patient

Patient with history of myasthenia gravis, metastatic melanoma presented with macules on both feet
Anti-programmed cell death-1 therapy for metastatic melanoma is associated with the development of immune-related cutaneous events

Melanoma Therapy Tied to Cutaneous Adverse Events

Anti-programmed cell death-1 therapy tied to lichenoid reactions, eczema, vitiligo