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Tag: Cancer: Skin

Pathologists have wide variability in treatment suggestions for melanocytic lesions

Pathologists Vary in Suggested Therapy for Melanocytic Lesions

Variation may lead to undertreatment or overtreatment of melanocytic lesions
MicroRNAs (miR-203 and miR-205) could be useful prognostic markers in cutaneous squamous cell carcinoma

MicroRNAs 203 and 205 Are Prognostic in Cutaneous SCC

miR-205 expression in tumors with pathologic features indicating poor prognosis, in invasion front
For superficial or nodular basal cell carcinoma at low-risk sites

Imiquimod Has Sustained Benefit for Basal Cell Carcinoma

Lower treatment success for imiquimod 5 percent than surgery, but rates similar at three, five years
Alcohol intake is associated with increased risk of melanoma

Alcohol Intake Linked to Increase in Risk of Melanoma

Correlation stronger for melanoma in relatively UV-spared sites versus UV-exposed sites
From 2000 to 2012 there was an increase in the incidence of sebaceous carcinoma

Incidence of Sebaceous Carcinoma Up From 2000 to 2012

Higher all-cause mortality among males, blacks, and for extraocular anatomic locations
Certain patients at high risk of melanoma may benefit from more tailored skin exams

Clinical Features Can Be Used to Tailor Melanoma Screening

A tailored surveillance program could lead to greater precision in melanoma prevention
Patients with melanoma treated with a combination of ipilimumab and nivolumab may be at risk for a potentially fatal T-cell-driven drug reaction

Myocarditis ID’d With Ipilimumab + Nivolumab in Melanoma

Case report describes two patients who developed fatal T-cell-driven drug reaction
In an non-integrated dermatopathology practice

Use of Term ‘Rule Out’ May Delay Dermatopathology Diagnosis

Use on requisition form linked to longer time to diagnosis, increased use of pathology stains, sections
For patients with cutaneous melanoma

Whites Have Longest Survival in Cutaneous Melanoma

For stages I and III, black patients have significantly lower survival, increased hazard ratios
Mohs micrographic surgery is efficacious for melanoma in situ (MIS) on the trunk and proximal extremities

Mohs Effective for Melanoma in Situ of Trunk, Extremities

Surgical margin of 9 mm needed to excise 97 percent of melanoma in situ