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House Speaker Nancy Pelosi has revealed a plan to lower the cost of medications for people on Medicare and those with private insurance.

House Speaker Unveils Plan to Lower Drug Costs

Plan would allow Medicare to negotiate prices for high-cost drugs
In a socioeconomically vulnerable minority population

Polypill Strategy Promising in Socioeconomically Vulnerable

Greater reductions in systolic blood pressure, LDL cholesterol levels with polypill in minority population
Adults aged 65 years and older should undergo annual cognitive health assessments to improve recognition of mild cognitive impairment

Seniors Should Undergo Annual Cognitive Health Assessment

After MCI diagnosis, patients should be counseled on treatment options; support needed for partners
Having a pharmacist in the emergency department significantly shortens the time to administration of treatment to reverse anticoagulation in patients with life-threatening bleeds or the need for urgent procedures

Pharmacist in ED Cuts Time to Tx to Reverse Anticoagulation

Time to 4F-PCC shorter for patients who have life-threatening bleeding, need urgent procedures
Many older patients with acute myeloid leukemia do not receive any active treatment

Many Older Patients With AML Not Receiving Active Treatment

No active treatment more likely with older age, lower household income, unmarried status, comorbidities
The risk for aortic and mitral regurgitation is increased with current and recent fluoroquinolone use

Aortic, Mitral Regurgitation Risk Up With Fluoroquinolone Use

Risk significantly increased for current use and recent use, but not past use within 61 to 365 days
Americans with rheumatic disease struggle to access affordable specialty care

Patients With Rheumatic Disease Often Have Trouble Accessing Care

Access issues include getting specialty appointments and affording treatment
Patients with chronic coronary artery disease or peripheral artery disease treated with the combination of rivaroxaban and aspirin face a greater risk for bleeding versus patients treated with aspirin alone

Combo Antithrombotic Therapy Increases Bleeding Risk

Greatest risk seen in first year of treatment, but benefits of combo therapy continue after one year
The rate of off-label ordering of systemic drugs has increased for children

Off-Label Ordering of Systemic Drugs Up for Children

Over time, off-label orders have increased for antihistamines, several psychotropics
When empirical antimicrobial therapy is initiated in patients with severe manifestations of sepsis

Initiating Empirical Tx for Sepsis Reduces Blood Culture Sensitivity

12 percent difference seen in proportion of positive blood cultures before and after antimicrobial therapy